UniProtKB record P00184 (CP1A1_MOUSE)
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CYP1A1 is a heme monooxygenase with broad endogenous and xenobiotic substrate scope.
"A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase)."
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UniProt supports ER/microsomal membrane localization and also lists mitochondrial and cytoplasmic context by homology.
"SUBCELLULAR LOCATION: Endoplasmic reticulum membrane. Mitochondrion inner membrane. Microsome membrane. Cytoplasm."
Falcon deep research report for mouse Cyp1a1
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Falcon identifies CYP1A1 as an ER/microsomal heme-thiolate monooxygenase in the AHR xenobiotic-response pathway.
"CYP1A1 is a membrane-associated heme-thiolate monooxygenase (cytochrome P450) classically found in microsomal/endoplasmic reticulum (ER) membranes as part of the mixed-function oxidase system."
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Falcon emphasizes PAHs, especially benzo[a]pyrene, as central mouse CYP1A1 substrate and toxicology context.
"Recent mouse work highlights polycyclic aromatic hydrocarbons (PAHs) as major CYP1A1 substrates/inducers; benzo[a]pyrene (B[a]P/BaP) is a prototypic example."
Gene Ontology annotation through association of InterPro records with GO terms
Gene Ontology annotation based on UniProtKB keyword mapping
Manual transfer of experimentally verified GO annotation data to orthologs
Phylogenetic inference of GO annotations using PANTHER
Gene Ontology annotation based on UniProtKB subcellular-location mapping
Automated transfer of experimentally verified GO annotation data to orthologs
Automatic transfer of experimentally verified GO annotation data by Ensembl Compara
Automated transfer of manually curated GO annotations by orthology
Combined automated annotation using UniProt, InterPro, Rhea, EC, and other mappings
Upregulation of CYP2e1 and CYP3a activities in histamine-deficient histidine decarboxylase gene targeted mice.
Cyp1a2 protects against reactive oxygen production in mouse liver microsomes.
Oral benzo[a]pyrene in Cyp1 knockout mouse lines: CYP1A1 important in detoxication, CYP1B1 metabolism required for immune damage independent of total-body burden and clearance rate.
Mouse lung CYP1A1 catalyzes the metabolic activation of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP).
7H-dibenzo[c,g]carbazole metabolism by the mouse and human CYP1 family of enzymes.
Enzyme-kinetic and immunochemical characteristics of mouse cDNA-expressed, microsomal, and purified CYP1A1 and CYP1A2.