Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Gene Ontology annotation based on curation of immunofluorescence data
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Automatic assignment of GO terms using logical inference, based on on inter-ontology links
Combined Automated Annotation using Multiple IEA Methods
Novel localization of OCTN1, an organic cation/carnitine transporter, to mammalian mitochondria.
DJ-1 binds to mitochondrial complex I and maintains its activity.
NDUFA4 is a subunit of complex IV of the mammalian electron transport chain.
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Definitive reclassification of NDUFA4 from Complex I to Complex IV based on proteomic, genetic, evolutionary, and biochemical analyses.
"NDUFA4 is a subunit of complex IV of the mammalian electron transport chain."
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NDUFA4 deletion does not perturb Complex I but reduces Complex IV levels and activity.
"NDUFA4 is a subunit of complex IV of the mammalian electron transport chain."
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NDUFA4 is required for CIV maintenance.
"NDUFA4 is a subunit of complex IV of the mammalian electron transport chain."
KIF14 negatively regulates Rap1a-Radil signaling during breast cancer progression.
Structure of the intact 14-subunit human cytochrome c oxidase.
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3.3 Angstrom cryo-EM structure of human Complex IV from supercomplex I1III2IV1.
"Structure of the intact 14-subunit human cytochrome c oxidase."
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NDUFA4 assigned as 14th subunit of CIV, located at the dimeric interface of previous crystal structures.
"Structure of the intact 14-subunit human cytochrome c oxidase."
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Intact CIV is proposed to be a monomer containing 14 subunits.
"Structure of the intact 14-subunit human cytochrome c oxidase."
Rewiring of the Human Mitochondrial Interactome during Neuronal Reprogramming Reveals Regulators of the Respirasome and Neurogenesis.
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Mass spectrometry-based co-fractionation profiling shows NDUFA4 interacting with both CI and CIV subunits in differentiated neuronal-like cells.
"Rewiring of the Human Mitochondrial Interactome during Neuronal Reprogramming Reveals Regulators of the Respirasome and Neurogenesis."
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Interaction with RAB5IF identified.
"Rewiring of the Human Mitochondrial Interactome during Neuronal Reprogramming Reveals Regulators of the Respirasome and Neurogenesis."
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Paper still refers to NDUFA4 as CI subunit despite its reclassification.
"Rewiring of the Human Mitochondrial Interactome during Neuronal Reprogramming Reveals Regulators of the Respirasome and Neurogenesis."
Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains.
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Large-scale neurodegenerative disease interactome mapping study.
"Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains."
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NDUFA4 interaction with DPF1 detected in yeast two-hybrid.
"Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains."
Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context.
Cloning of the human cDNA sequence encoding the NADH:ubiquinone oxidoreductase MLRQ subunit.
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Original cloning of NDUFA4 cDNA, predating the reclassification to Complex IV.
"Cloning of the human cDNA sequence encoding the NADH:ubiquinone oxidoreductase MLRQ subunit."
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Incorrectly classified NDUFA4 as a Complex I subunit.
"Cloning of the human cDNA sequence encoding the NADH:ubiquinone oxidoreductase MLRQ subunit."
cDNA of eight nuclear encoded subunits of NADH:ubiquinone oxidoreductase: human complex I cDNA characterization completed.
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Characterized NDUFA4 cDNA as part of Complex I characterization effort.
"cDNA of eight nuclear encoded subunits of NADH:ubiquinone oxidoreductase: human complex I cDNA characterization completed."
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Predates the reclassification to Complex IV.
"cDNA of eight nuclear encoded subunits of NADH:ubiquinone oxidoreductase: human complex I cDNA characterization completed."
Electron transfer from reduced cytochrome c to molecular oxygen
CO binds to Cytochrome c oxidase
MT-CO3, COX6A,B,7A and NDUFA4 bind to holo-MT-CO1,2 complex
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Reactome reaction documenting NDUFA4 assembly into Complex IV during CIV biogenesis.
"MT-CO3, COX6A,B,7A and NDUFA4 bind to holo-MT-CO1,2 complex"
Deep research on NDUFA4/COXFA4 function
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Comprehensive literature review confirming NDUFA4 as CIV subunit.
"Deep research on NDUFA4/COXFA4 function"
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C15ORF48/miR-147 axis regulates NDUFA4 post-transcriptionally.
"Deep research on NDUFA4/COXFA4 function"
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Biallelic NDUFA4 deletion causes Leigh-like syndrome (MC4DN21).
"Deep research on NDUFA4/COXFA4 function"
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In situ cryo-EM confirms NDUFA4 in native CIV/respirasomes.
"Deep research on NDUFA4/COXFA4 function"