Gene Ontology annotation through association of InterPro records with GO terms

Use of the ND evidence code for Gene Ontology (GO) terms

Annotation inferences using phylogenetic trees

Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt

Gene Ontology annotation based on curation of immunofluorescence data

COX16 is required for assembly of cytochrome c oxidase in human cells and is involved in copper delivery to COX2.

COX16 promotes COX2 metallation and assembly during respiratory complex IV biogenesis.

A reference map of the human binary protein interactome.

Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context.

A novel variant in COX16 causes cytochrome c oxidase deficiency, severe fatal neonatal lactic acidosis, encephalopathy, cardiomyopathy, and liver dysfunction.

UniProtKB entry Q9P0S2 (COX16_HUMAN)

Metallochaperone inserts Cu2+ into MT-CO1

MT-CO1 and MT-CO2 complexes associate, installing heme moieties

Metallochaperone inserts 2Cu2+ into MT-CO2