Gene Ontology annotation through association of InterPro records with GO terms

Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity

Annotation inferences using phylogenetic trees

Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt

Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara

Direct interactions between the heterotrimeric G protein subunit G beta 5 and the G protein gamma subunit-like domain-containing regulator of G protein signaling 11: gain of function of cyan fluorescent protein-tagged G gamma 3.

MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis.

X-ray structure of the mammalian GIRK2-βγ G-protein complex.

Comprehensive analysis of heterotrimeric G-protein complex diversity and their interactions with GPCRs in solution.

A Mutation in the G-Protein Gene GNB2 Causes Familial Sinus Node and Atrioventricular Conduction Dysfunction.

Phase-plate cryo-EM structure of a class B GPCR-G-protein complex.

Cryo-EM structure of the serotonin 5-HT(1B) receptor coupled to heterotrimeric G(o).

Cryo-electron microscopy structure of the glucagon receptor with a dual-agonist peptide.

Structure of a D2 dopamine receptor-G-protein complex in a lipid membrane.

Structural insights into the lipid and ligand regulation of serotonin receptors.

Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.

Structural basis for recognition of anti-migraine drug lasmiditan by the serotonin receptor 5-HT(1F)-G protein complex.

OpenCell: Endogenous tagging for the cartography of human cellular organization.

Binding of Gbeta/gamma to GIRK/Kir3 channels

Association of GABA B receptor with G protein beta-gamma subunits

Activation of GIRK/Kir3 Channels

The receptor:G-protein complex dissociates

Thrombin-activated PARs activate G12/13

Thrombin-activated PARs activate Gq

The high affinity receptor complex binds to G-protein

The receptor:G-protein complex releases GDP

The receptor:G-protein complex binds GTP

G-protein beta-gamma subunits rebind the alpha-GDP subunit

Liganded Gs-activating GPCR acts as a GEF for Gs

Liganded Gq/11-activating GPCRs act as GEFs for Gq/11

Liganded Gi-activating GPCR acts as a GEF for Gi

Activated P2Y purinoceptor 12 binds G-protein Gi

Gi activation by P2Y purinoceptor 12

Dissociation of the P2Y purinoceptor 12:Gi complex

Gbeta:gamma recruits PI3K gamma

G beta:gamma activated PI3Kgamma converts PIP2 to PIP3

Activated prostacyclin receptor binds G-protein Gs

Gs activation by prostacyclin receptor

WNT:FZD complex promotes G-protein nucleotide exchange

G-protein subunits dissociate from WNT:FZD complex

Thrombin-activated PARs binds G-protein Gq

Thrombin-activated PARs:Gq (active) dissociate

Thrombin-activated PARs:G12/13 (active) dissociate

Gbeta:gamma activation of PLC beta

PLC beta-mediated PIP2 hydrolysis

Dissociation of the P2Y purinoceptor 1:Gq complex

Opsins act as GEFs for G alpha-t

Activated TP receptor binds G-proten Gq

Gq activation by TP receptor

Dissociation of the TP:Gq complex

Activated TP receptor binds G-protein G13

G13 activation by TP receptor

Dissociation of the TP:G13 complex

Activation of GRIK3 homomer

PDCL promotes formation of G-beta:G-gamma heterodimers

The Ligand:GPCR:Gs complex dissociates

Liganded Gs-activating GPCRs bind inactive heterotrimeric Gs

Liganded Gz-activating GPCRs bind inactive heterotrimeric G-protein Gz

Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq

The Ligand:GPCR:Gq complex dissociates

Liganded Gz-activating GPCR acts as a GEF for Gz

The Ligand:GPCR:Gi complex dissociates

Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi

Inactive G alpha (z) reassociates with G beta:gamma

Inactive G alpha (q) reassociates with G beta:gamma

Inactive G alpha (i) reassociates with G beta:gamma

Inactive G alpha (s) reassociates with G beta:gamma

The Ligand:GPCR:G12/13 complex dissociates

The Ligand:GPCR:Gz complex dissociates

Liganded G12/13-activating GPCRs bind inactive heterotrimeric G-protein G12/13

Liganded G12/13-activating GPCR acts as a GEF for G12/13

Inactive G alpha (12/13) reassociates with G beta:gamma

Glucagon:GCGR mediates GTP-GDP exchange

G-protein alpha releases G-protein heterotrimer from PDCL

G beta-gamma complex and PIP3 recruit BTK to membrane

BTK in PIP3:BTK:G beta-gamma complex is activated

PIP3:BTK:G beta-gamma complex dissociates to Active BTK, PIP3 and G beta-gamma complex

Active PAK1 and Active CDC42 dissociates from GNB/GNG:PAK1:ARHGEF6:CDC42 complex

CDC42 in GNB/GNG:PAK1:ARHGEF6:CDC42 is activated

PAK1:ARHGEF6 complex binds G-protein beta-gamma complex

PAK1 in GNB/GNG:PAK1:ARHGEF6:Active CDC42 is activated

CDC42 binds GNB/GNG:PAK1:ARHGEF6 complex

Opsins binds G alpha-t

G-alpha(t):G-beta-gamma:Opsins complex dissociates to active G-alpha(t)

G-proteins dissociate from plasma-membrane estrogen receptors

Heterotrimeric G protein (i) binds membrane-associated ESRs:ESTG

ESTG stimulates GTP exchange on GPER:heterotrimeric G-protein s

GPER:Heterotrimeric G-protein Gs binds ESTG

ESTG-stimulated dissociation of GPER:heterotrimeric G-protein (s) complex

ADORA2B:Ade-Rib:GsGTP dissociates

ADORA2B (in Ade-Rib:ADORA2B:Heterotrimeric G-protein Gs) exchanges GDP for GTP on Gs

ADORA2B:Ade-Rib binds heterometric G-protein Gs

UniProt entry P59768 (GNG2_HUMAN)

Ligand-dependent G protein dynamics underlying opioid efficacy.