Gene Ontology annotation through association of InterPro records with GO terms

Annotation inferences using phylogenetic trees

Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservation of the subcellular location

GO_REF:0000052

Gene Ontology annotation based on curation of immunofluorescence data

PMID:9344664

Identification and characterization of the gene encoding a new member of the alpha-crystallin/small hsp family, closely linked to the alphaB-crystallin gene in a head-to-head manner.

PMID:9490724

MKBP, a novel member of the small heat shock protein family, binds and activates the myotonic dystrophy protein kinase.

HSPB2/MKBP is a small HSP that binds DMPK, enhances its kinase activity and protects it from heat-induced inactivation; it forms an oligomeric muscle-cytosol complex distinct from the alphaB-crystallin/HSP27 complex and is not induced by heat shock.

PMID:14594798

Interaction of human HSP22 (HSPB8) with other small heat shock proteins.

PMID:19464326

HSPB7 is a SC35 speckle resident small heat shock protein.

HSPB2 localizes to both the cytoplasm and the nucleus (nuclear foci).

PMID:23188086

Binding determinants of the small heat shock protein, αB-crystallin: recognition of the 'IxI' motif.

PMID:25556234

New host factors important for respiratory syncytial virus (RSV) replication revealed by a novel microfluidics screen for interactors of matrix (M) protein.

PMID:26465331

Characterization of the Cardiac Overexpression of HSPB2 Reveals Mitochondrial and Myogenic Roles Supported by a Cardiac HspB2 Interactome.

Cardiac HSPB2 overexpression is cardioprotective in ischemia (reduced infarct, maintained ATP); HSPB2 has a myofibrillar/mitochondrial cardiac interactome and GAPDH was validated as a client protein via chaperone assays.

PMID:32296183

A reference map of the human binary protein interactome.

PMID:32814053

Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains.

PMID:33961781

Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.

file:human/HSPB2/HSPB2-uniprot.txt

UniProt entry Q16082 (HSPB2_HUMAN), Heat shock protein beta-2 (MKBP)

Small heat-shock protein (HSP20/alpha-crystallin family) expressed in skeletal muscle and heart but not lens; binds and may activate DMPK; localizes to cytoplasm and nucleus (nuclear foci).