Gene Ontology annotation through association of InterPro records with GO terms
Combined Automated Annotation using Multiple IEA Methods
UniProtKB entry for pqqF (Coenzyme PQQ synthesis protein F)
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"Required for coenzyme pyrroloquinoline quinone (PQQ)"
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"Belongs to the peptidase M16 family."
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"PATHWAY: Cofactor biosynthesis; pyrroloquinoline quinone biosynthesis."
QuickGO GOA annotations for pqqF
A two-component protease in Methylorubrum extorquens with high activity toward the peptide precursor of the redox cofactor pyrroloquinoline quinone.
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"can rapidly catalyze cleavage of PqqA into smaller peptides"
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"demonstrated the formation of a complex PqqF/PqqG"
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"a protease/peptidase required for the excision of an early, cross-linked di-amino acid precursor to pyrroloquinoline quinone"
Falcon deep research report for pqqF (Q88QV3, P. putida KT2440)
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"PqqF/PqqG are **M16-family zinc metallopeptidases** acting on the PQQ precursor peptide PqqA"
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"zinc-dependent M16-family endopeptidase that participates in **processing the PqqA precursor peptide**"
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"pqqF is transcribed independently"
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"two-component M16B metallopeptidase"
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"high activity toward PqqA in vitro and binds as a heterodimer with **KD ≈ 300 ± 70 nM**"
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"catalytic cavity volume of ~**9400 ų**, suggested to define specificity for small peptide substrates like PqqA"
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"PqqF is variably present and may be replaceable by non-specific proteases in some systems"
OpenScientist research report for pqqF (Q88QV3, P. putida KT2440)