Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Gene Ontology annotation based on curation of immunofluorescence data
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
Identification of APC2, a homologue of the adenomatous polyposis coli tumour suppressor.
-
Mammalian APC2 regulates beta-catenin–Tcf activity in the reported transcription assay.
"Like APC, APC2 regulates the formation of active betacatenin-Tcf
complexes"
-
Two SAMP domains are required for the reported mammalian APC2 interaction with conductin, providing mechanistic support for destruction-complex participation.
"shown to contain two SAMP domains, both of which are required for binding to
conductin."
EB3, a novel member of the EB1 family preferentially expressed in the central nervous system, binds to a CNS-specific APC homologue.
APCL, a central nervous system-specific homologue of adenomatous polyposis coli tumor suppressor, binds to p53-binding protein 2 and translocates it to the perinucleus.
Human APC2 localization and allelic imbalance.
-
Endogenous human APC2 has cytoplasmic, Golgi and actin-associated pools.
"endogenous APC2 is diffusely distributed in the cytoplasm and colocalizes with
both the Golgi apparatus and actin filaments."
Loss-of-Function Mutation in APC2 Causes Sotos Syndrome Features.
-
A disease-associated APC2 frameshift impairs neuronal cytoskeletal regulation.
"a homozygous frameshift mutation in the APC2 gene by
whole-exome sequencing, which resulted in the loss of function of cytoskeletal
regulation in neurons."
A novel GSK3-regulated APC:Axin interaction regulates Wnt signaling by driving a catalytic cycle of efficient βcatenin destruction.
Downregulation of beta-catenin by human Axin and its association with the APC tumor suppressor, beta-catenin and GSK3 beta.
-
The accessible abstract establishes an Axin/APC complex but does not independently resolve the APC2 NAS derivation.
"Human Axin (hAxin) binds directly to beta-catenin, GSK3 beta, and APC
in vitro"
Identification of a brain-specific APC homologue, APCL, and its interaction with beta-catenin.
-
The human APCL beta-catenin-binding fragment lowers intracellular beta-catenin.
"Like APC, this domain of APCL was
able to bind to beta-catenin and deplete the intracellular beta-catenin pool."
APC2 plays an essential role in axonal projections through the regulation of microtubule stability.
Directional neuronal migration is impaired in mice lacking adenomatous polyposis coli 2.
APC2 controls dendrite development by promoting microtubule dynamics.
APC2 is critical for ovarian WNT signalling control, fertility and tumour suppression.
Bi-allelic Loss of Human APC2, Encoding Adenomatous Polyposis Coli Protein 2, Leads to Lissencephaly, Subcortical Heterotopia, and Global Developmental Delay.
APC2 annotation review notes