Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Novel transcription coactivator complex containing activating signal cointegrator 1.
Mutations in Subunits of the Activating Signal Cointegrator 1 Complex Are Associated with Prenatal Spinal Muscular Atrophy and Congenital Bone Fractures.
Architecture of the human interactome defines protein communities and disease networks.
A ubiquitin-dependent signalling axis specific for ALKBH-mediated DNA dealkylation repair.
RNA ligase-like domain in activating signal cointegrator 1 complex subunit 1 (ASCC1) regulates ASCC complex function during alkylation damage.
Identification of a novel trigger complex that facilitates ribosome-associated quality control in mammalian cells.
A reference map of the human binary protein interactome.
The ASC-1 Complex Disassembles Collided Ribosomes.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
A distinct mammalian disome collision interface harbors K63-linked polyubiquitination of uS10 to trigger hRQT-mediated subunit dissociation.
The interaction of DNA repair factors ASCC2 and ASCC3 is affected by somatic cancer mutations.
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The ASCC2 N-terminal region forms a compact unit clasped by the ASCC3 N-terminal arms in a high-affinity, evolutionarily conserved interface, and somatic cancer mutations mapping to this interface reduce ASCC2-ASCC3 affinity, suggesting a loss-of-scaffold-coupling disease principle rather than loss of ASCC3 helicase catalysis.
The ASCC2 CUE domain in the ALKBH3-ASCC DNA repair complex recognizes adjacent ubiquitins in K63-linked polyubiquitin.
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The ASCC2 CUE domain selectively binds K63-linked diubiquitin by contacting both the distal and proximal ubiquitin, and N-terminal alpha1-helix residues are required for ASCC2 recruitment to alkylation-damage sites, providing a structural basis for K63-linkage-specific ubiquitin recognition.
Extended DNA threading through a dual-engine motor module of the activating signal co-integrator 1 complex.
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TRIP4 and the DNA/RNA dealkylase ALKBH3 bind ASCC3 mutually exclusively, directing the ASCC3 motor module either to ribosome quality control or to DNA alkylation repair, while ASCC2 functions as the shared K63-polyubiquitin reader across both assemblies.
Ribosomal collision is not a prerequisite for ZNF598-mediated ribosome ubiquitination and disassembly of ribosomal complexes by ASCC.
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In vitro reconstitution shows ASCC can disassemble ubiquitinated monosomes, polysome queues, and 48S complexes without obligatory ribosome collision, provided sufficiently long K63-linked ubiquitin chains and at least ~30-35 nucleotides of 3' mRNA downstream of the P site are present.
Ubiquitin-dependent translation control mechanisms: Degradation and beyond.
DNA Alkylation Damage by Nitrosamines and Relevant DNA Repair Pathways.
Oxidative demethylation of 1-meA damaged DNA By ALKBH3
Oxidative demethylation of 3-meC damaged DNA By ALKBH3
Oxidative dealkylation of 1-EtA damaged DNA by ABH3
ALKBH3 associated with ASCC1:ASCC2:ASCC3 binds alkylated dsDNA containing 3-meC
ALKBH3 associated with ASCC1:ASCC2:ASCC3 binds alkylated dsDNA containing 1-meA
ALKBH3 in complex with ASCC1:ASCC2:ASCC3 binds alkylated DNA containing 1-etA
RQT complex binds K63polyUb-80S ribosome:no-go mRNA:peptidyl-tRNA with nascent peptide
RQT complex:K63polyUb-80S ribosome dissociates yielding K63polyUb-40S subunit and 60S subunit:peptidyl-tRNA with nascent peptide
UniProtKB record for human ASCC2
Proteostasis PN projected annotations report
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ASCC2 is projected to GO:0072344 as already present and to GO:0006515 as a candidate new-to-GOA group-level RQC annotation.
"ASCC2 Translation|Cytosolic translation|Ribosome-associated QC|Ribosomal rescue"