Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniPathway vocabulary mapping
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
UniProtKB entry P15538 (C11B1_HUMAN), Cytochrome P450 11B1, mitochondrial
The human steroid hydroxylases CYP1B1 and CYP11B2.
Modulation of aldosterone and cortisol synthesis on the molecular level.
[Hypoglycemia due to a disorder of adrenal cortical regulation].
Purification and functional characterization of human 11beta hydroxylase expressed in Escherichia coli.
Regulation of aldosterone and cortisol production by the transcriptional repressor neuron restrictive silencer factor.
A mutation in CYP11B1 (Arg-448----His) associated with steroid 11 beta-hydroxylase deficiency in Jews of Moroccan origin.
Cloning and expression of a cDNA for human cytochrome P-450aldo as related to primary aldosteronism.
Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context.
Mutations in the CYP11B1 gene causing congenital adrenal hyperplasia and hypertension cluster in exons 6, 7, and 8.
Glucocorticoid biosynthesis
Defective CYP11B1 does not oxidise 11DCORT
Studies on the origin of circulating 18-hydroxycortisol and 18-oxocortisol in normal human subjects.
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Both human enzymes perform cortisol 18-hydroxylation, while subsequent 18-oxidation is restricted to aldosterone synthase.
"Both enzymes could synthesize
18-OHF from cortisol, but only AS could synthesize 18-oxoF."
Elaboration of the Corticosteroid Synthesis Pathway in Primates through a Multistep Enzyme.
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Ancestral reconstruction distinguishes retained multistep CYP11B2 chemistry from CYP11B1 specialization following the Old World primate duplication.
"the
primate ancestor of the CYP11B1 and CYP11B2 paralogs had moderate ability to
synthesize both cortisol and aldosterone."