Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Gene Ontology annotation based on curation of immunofluorescence data
Electronic Gene Ontology annotations created by ARBA machine learning models
The XRCC2 and XRCC3 repair genes are required for chromosome stability in mammalian cells.
Identification and purification of two distinct complexes containing the five RAD51 paralogs.
Involvement of Rad51C in two distinct protein complexes of Rad51 paralogs in human cells.
RAD51C is required for Holliday junction processing in mammalian cells.
Homologous recombination generates T-loop-sized deletions at human telomeres.
Cellular localization of human Rad51C and regulation of ubiquitin-mediated proteolysis of Rad51.
Ring-shaped Rad51 paralog protein complexes bind Holliday junctions and replication forks as visualized by electron microscopy.
Discovery of a novel function for human Rad51: maintenance of the mitochondrial genome.
Normal mammalian cells negatively regulate telomere length by telomere trimming.
hSWS1·SWSAP1 is an evolutionarily conserved complex required for efficient homologous recombination repair.
The RAD51 paralogs ensure cellular protection against mitotic defects and aneuploidy.
Rad51 paralog complexes BCDX2 and CX3 act at different stages in the BRCA1-BRCA2-dependent homologous recombination pathway.
HELQ promotes RAD51 paralogue-dependent repair to avert germ cell loss and tumorigenesis.
Breast cancer-associated missense mutants of the PALB2 WD40 domain, which directly binds RAD51C, RAD51 and BRCA2, disrupt DNA repair.
NUCKS1 is a novel RAD51AP1 paralog important for homologous recombination and genome stability.
Mammalian RAD51 paralogs protect nascent DNA at stalled forks and mediate replication restart.
A human interactome in three quantitative dimensions organized by stoichiometries and abundances.
A balance between elongation and trimming regulates telomere stability in stem cells.
Discovery of mutations in homologous recombination genes in African-American women with breast cancer.
A protein interaction landscape of breast cancer.
Correction of chromosomal instability and sensitivity to diverse mutagens by a cloned cDNA of the XRCC3 DNA repair gene.
Isolation and characterization of RAD51C, a new human member of the RAD51 family of related genes.
XRCC2 and XRCC3, new human Rad51-family members, promote chromosome stability and protect against DNA cross-links and other damages.
CX3 complex binds D-loop structures
BLM mediates dissolution of double Holliday junction
MUS81:EME1,EME2 cleaves D-loop
Resolution of D-loops cleaved by MUS81:EME1 or MUS81:EME2
Resolution of Holliday junctions cleaved by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2)
Ligation of DNA and formation of Holliday structures following repair synthesis
Cleavage of Holliday junctions by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2)
D-loop dissociation and strand annealing
D-loop extension by DNA polymerases
Distinct functions of mammalian RAD51 paralogs in genome maintenance.
Cryo-electron microscopic visualization of RAD51 filament assembly and end-capping by XRCC3-RAD51C-RAD51D-XRCC2.
BCDX2-CX3 and DX2-CX3 complexes assemble and stabilize RAD51 filaments.
Structural insight into how RAD51 paralog exchange regulates RAD51 filament formation.
ATM- and ATR-mediated phosphorylation of XRCC3 regulates DNA double-strand break-induced checkpoint activation and repair.
RAD51C-XRCC3 complex regulates FANCM-mediated R-loop resolution to safeguard genome integrity.
RAD51C/XRCC3 Facilitates Mitochondrial DNA Replication and Maintains Integrity of the Mitochondrial Genome.
XRCC3 controls the fidelity of homologous recombination: roles for XRCC3 in late stages of recombination.
Mammalian recombination-repair genes XRCC2 and XRCC3 promote correct chromosome segregation.
RAD51 paralogs synergize with RAD51 to protect reversed forks from cellular nucleases.
RAD51C-XRCC3 structure and cancer patient mutations define DNA replication roles.