hemF (P36553, Escherichia coli K-12) curation notes

Sources and deep research

• Deep research was unavailable (the just deep-research perplexity route failed in this
  environment: missing template in the sparse checkout and no provider access). The review rests
  on UniProt P36553, the GOA-cited publications in publications/, and the comparator reviews
  genes/PSEPK/hemF and genes/ECOLI/hemN.

Evidence

• Cloned by complementation of yeast HEM13 PMID:8300522.
• Enzymology PMID:12975365; Mn
  restores activity after chelation PMID:12975365. Abstract only.
• Dimer PMID:13129604.
• OxyR induction and requirement during H2O2 stress PMID:25664592. Either HemF or HemN suffices in unstressed aerobic cells PMID:25664592.

Decisions

• GO:0033194 response to hydroperoxide (IEP, IMP): MODIFY to GO:0070301 cellular response to
  hydrogen peroxide. GO:0033194 is defined for hydroperoxides (monosubstitution products of HOOH);
  the stimulus in PMID:25664592 is H2O2 itself.
• GO:0046906 tetrapyrrole binding (IMP): KEEP_AS_NON_CORE (substrate/inhibitor binding entailed by
  activity).
• Homodimerization rows: KEEP_AS_NON_CORE, as in PSEPK/hemF.
• Porphyrin biosynthesis IEA: MODIFY to GO:0006785 heme B biosynthetic process.