Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping
Gene Ontology annotation based on curation of immunofluorescence data
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
Human VPS34 and p150 are Rab7 interacting partners.
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RAB7A interacts with PI3K complex VPS34/p150 on late endosomes
"The hVPS34/p150 complex colocalized with rab7 on late endosomes"
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RAB7A nucleotide cycling regulates VPS34 activity
"Rab7 is required for late endosomal transport"
Cargo-selective endosomal sorting for retrieval to the Golgi requires retromer.
Interconnections of CLN3, Hook1 and Rab proteins link Batten disease to defects in the endocytic pathway.
Structural basis for recruitment of RILP by small GTPase Rab7.
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Crystal structure of RAB7A-RILP complex solved
"The crystal structure of Rab7-GTP in complex with the Rab7 binding domain of RILP reveals that Rab7 interacts with RILP specifically via two distinct areas"
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RILP binds GTP-bound RAB7A through switch regions
"Rab7 interacts with RILP specifically via two distinct areas, with the first one involving the switch and interswitch regions and the second one consisting of RabSF1 and RabSF4"
The oxysterol-binding protein homologue ORP1L interacts with Rab7 and alters functional properties of late endocytic compartments.
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ORP1L binds GTP-bound RAB7A
"ORP1L interacts physically with Rab7, preferentially with its GTP-bound form"
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ORP1L-RAB7A complex regulates late endosome properties
"ORP1L binds to Rab7, modifies its functional cycle, and can interfere with LE/lysosome organization and endocytic membrane trafficking"
Novel RING E3 ubiquitin ligases in breast cancer.
RILP interacts with VPS22 and VPS36 of ESCRT-II and regulates their membrane recruitment.
Functional characterization of Rab7 mutant proteins associated with Charcot-Marie-Tooth type 2B disease.
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CMT2B mutations increase nucleotide exchange rates
"all three proteins exhibited higher nucleotide exchange rates and hydrolyzed GTP slower than the wild-type protein"
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Mutants show slower GTP hydrolysis
"all three proteins exhibited higher nucleotide exchange rates and hydrolyzed GTP slower than the wild-type protein"
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Mutants are predominantly GTP-bound (82-89% vs 23% wild-type)
"whereas 23% of overexpressed wild-type Rab7 was GTP bound in HeLa cells, the large majority of the mutant proteins (82-89%) were in the GTP-bound form"
The Salmonella virulence protein SifA is a G protein antagonist.
Large-scale proteomics and phosphoproteomics of urinary exosomes.
Rab7: roles in membrane trafficking and disease.
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Comprehensive review of RAB7A functions
"Rab7 plays critical roles in the endocytic processes"
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Role in endosomal sorting, lysosome biogenesis, phagocytosis
"Rab7 participates in multiple regulation mechanisms in endosomal sorting, biogenesis of lysosome"
Membrane recruitment of the cargo-selective retromer subcomplex is catalysed by the small GTPase Rab7 and inhibited by the Rab-GAP TBC1D5.
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RAB7A catalyzes retromer recruitment to endosomes
"Membrane recruitment of the cargo-selective retromer subcomplex is catalysed by the small GTPase Rab7"
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TBC1D5 GAP inhibits this process
"Membrane recruitment of the cargo-selective retromer subcomplex is catalysed by the small GTPase Rab7 and inhibited by the Rab-GAP TBC1D5"
Cholesterol sensor ORP1L contacts the ER protein VAP to control Rab7-RILP-p150 Glued and late endosome positioning.
An initial step of GAS-containing autophagosome-like vacuoles formation requires Rab7.
Disease mutations in Rab7 result in unregulated nucleotide exchange and inappropriate activation.
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Crystal structure of L129F mutant RAB7A at 2.8 A
"We determined the crystal structure of GTP-bound L129F mutant Rab7 at 2.8 Å resolution revealing an alteration to the nucleotide binding pocket, but no impact on the catalytic region of Rab7"
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CMT2B mutations permit unregulated nucleotide exchange
"We found that Rab7 mutants have an increased rate of GTP dissociation relative to wild-type"
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No intrinsic GTPase defect when GTP is in constant supply
"when GTP is in constant supply (as is the case in vivo), catalytic activity in disease mutants is not significantly impaired"
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Increased interaction with effector proteins
"Specifically, Rab7 disease mutants L129F and V162M and the constitutively active mutant Q67L showed increased interaction with Vps13C and ORP1L"
FYCO1 is a Rab7 effector that binds to LC3 and PI3P to mediate microtubule plus end-directed vesicle transport.
MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis.
Localization of low molecular weight GTP binding proteins to exocytic and endocytic compartments.
Rab GTPases regulating phagosome maturation are differentially recruited to mycobacterial phagosomes.
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RAB7A regulates phagosomal acidification
"Rab7, Rab20 and Rab39 regulated phagosomal acidification"
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RAB7A controls cathepsin D recruitment
"Rab7, Rab20, Rab22b, Rab32, Rab34, Rab38 and Rab43 controlled the recruitment of cathepsin D to the phagosome"
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Differential recruitment to S. aureus vs M. tuberculosis phagosomes
"We compared the localization of 42 distinct Rab GTPases to phagosomes containing either Staphylococcus aureus or M. tb"
Proteolytic targeting of Rab29 by an effector protein distinguishes the intracellular compartments of human-adapted and broad-host Salmonella.
Rab7A is required for efficient production of infectious HIV-1.
Lysosomal targeting of phafin1 mediated by Rab7 induces autophagosome formation.
Neuronal ceroid lipofuscinosis protein CLN3 interacts with motor proteins and modifies location of late endosomal compartments.
The role of ceroid lipofuscinosis neuronal protein 5 (CLN5) in endosomal sorting.
Syndecan-syntenin-ALIX regulates the biogenesis of exosomes.
In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
A mechanism for retromer endosomal coat complex assembly with cargo.
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RAB7A role in retromer membrane docking
"membrane recruitment of retromer is mediated by bivalent recognition of an effector of PI3K, SNX3, and the RAB7A GTPase"
PLEKHM1 regulates Salmonella-containing vacuole biogenesis and infection.
RUN and FYVE domain-containing protein 4 enhances autophagy and lysosome tethering in response to Interleukin-4.
A human interactome in three quantitative dimensions organized by stoichiometries and abundances.
Parkin Modulates Endosomal Organization and Function of the Endo-Lysosomal Pathway.
Characterization of a Relatively Malignant Form of Osteopetrosis Caused by a Novel Mutation in the PLEKHM1 Gene.
Parkinson Disease-linked Vps35 R524W Mutation Impairs the Endosomal Association of Retromer and Induces α-Synuclein Aggregation.
The Rab7 effector PLEKHM1 binds Arl8b to promote cargo traffic to lysosomes.
Regulation of the small GTPase Rab1 function by a bacterial glucosyltransferase.
VPS13A is closely associated with mitochondria and is required for efficient lysosomal degradation.
Structural basis of human ORP1-Rab7 interaction for the late-endosome and lysosome targeting.
Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains.
Identification of Required Host Factors for SARS-CoV-2 Infection in Human Cells.
The endolysosomal adaptor PLEKHM1 is a direct target for both mTOR and MAPK pathways.
The SARS-CoV-2 protein ORF3a inhibits fusion of autophagosomes with lysosomes.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
C5orf51 is a component of the MON1-CCZ1 complex and controls RAB7A localization and stability during mitophagy.
C9orf72-catalyzed GTP loading of Rab39A enables HOPS-mediated membrane tethering and fusion in mammalian autophagy.
The HEAT repeat protein HPO-27 is a lysosome fission factor.
Molecular cloning and expression analysis of the human Rab7 GTP-ase complementary deoxyribonucleic acid.
Transport of antigen loaded MHC II molecules to surface
Exocytosis of secretory granule membrane proteins
TBC1D2A accelerates GTP hydrolysis by RAB7
TBC1D15 accelerates GTP hydrolysis by RAB7
MON1:CCZ1 exchanges GTP for GDP on RAB7
NdkA dephosphorylates RAB5A:GTP,RAB7A:GTP
Deep research report on RAB7A
Cyberian deep research on RAB7A function