GO_REF:0000002

Gene Ontology annotation through association of InterPro records with GO terms

GO_REF:0000033

Annotation inferences using phylogenetic trees

KCTD8 is phylogenetically related to KCTD12 and KCTD16, supporting conserved function as GABA-B receptor auxiliary subunits

GO_REF:0000044

Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping

GO_REF:0000107

Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara

GO_REF:0000117

Electronic Gene Ontology annotations created by ARBA machine learning models

GO_REF:0000120

Combined Automated Annotation using Multiple IEA Methods

PMID:32296183

A reference map of the human binary protein interactome

PMID:36931259

A central chaperone-like role for 14-3-3 proteins in human cells

DOI:10.1038/nature08964

Native GABAB receptors are heteromultimers with a family of auxiliary subunits

DOI:10.1038/s41586-019-0990-0

Structural basis for KCTD-mediated rapid desensitization of GABAB signalling

KCTD BTB pentamers bind GB2 C-terminal peptide
H1 domain symmetrically engages five G-beta-gamma copies
KCTD8 lacks desensitization motif present in KCTD12, leading to non-desensitizing responses

DOI:10.1073/pnas.1903024116

Structural basis for auxiliary subunit KCTD16 regulation of the GABA <sub>B</sub> receptor

DOI:10.7554/eLife.68274

GABAB receptor auxiliary subunits modulate Cav2.3-mediated release from medial habenula terminals

KCTD8 localizes to presynaptic active zones in MHb-IPN pathway
KCTD8 directly binds Cav2.3 calcium channels
KCTD8 knockout reduces basal release probability from 0.26 to 0.12
KCTD8 overexpression decreases paired-pulse ratio (increases release probability)

DOI:10.1523/JNEUROSCI.1676-21.2021

KCTD8 and KCTD12 Facilitate Axonal Expression of GABA<sub>B</sub>Receptors in Habenula Cholinergic Neurons

KCTD8 strongly expressed in somata and axonal terminals of ChAT+ habenula neurons
Triple KO of KCTD8/12/16 reduced axonal GABA-B receptor expression
KCTD8 required for presynaptic GABA-B-mediated potentiation

DOI:10.1016/j.neuron.2014.04.015

Auxiliary GABAB Receptor Subunits Uncouple G Protein βγ Subunits from Effector Channels to Induce Desensitization

file:human/KCTD8/KCTD8-deep-research-falcon.md

Deep research summary for KCTD8

KCTD8 is a BTB/POZ domain-containing auxiliary subunit of GABA-B receptors
KCTD8 forms pentamers via BTB domain that bind GABA-B2 C-terminus
H1 domain cooperatively binds G-protein beta-gamma to modulate signaling kinetics
KCTD8 lacks the desensitization motif present in KCTD12, promoting sustained signaling
KCTD8 localizes to presynaptic active zones and binds Cav2.3 calcium channels

file:human/KCTD8/KCTD8-deep-research-cyberian.md

Cyberian deep research on KCTD8 function