Annotation inferences using phylogenetic trees
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
Deletion of Lys224 in regulatory domain 4 of Factor H reveals a novel pathomechanism for dense deposit disease (MPGN II).
Studies on the interactions between C-reactive protein and complement proteins.
The factor H variant associated with age-related macular degeneration (His-384) and the non-disease-associated form bind differentially to C-reactive protein, fibromodulin, DNA, and necrotic cells.
Y402H polymorphism of complement factor H affects binding affinity to C-reactive protein.
Complement factor H allotype 402H is associated with increased C3b opsonization and phagocytosis of Streptococcus pyogenes.
Complement factor H binds to denatured rather than to native pentameric C-reactive protein.
Binding of the long pentraxin PTX3 to factor H: interacting domains and function in the regulation of complement activation.
Human complement factor H-related protein 4 binds and recruits native pentameric C-reactive protein to necrotic cells.
Neisseria meningitidis recruits factor H using protein mimicry of host carbohydrates.
Complement factor H, a marker of self protects against experimental autoimmune encephalomyelitis.
Electrostatic interactions contribute to the folded-back conformation of wild type human factor H.
Synergy between ficolin-2 and pentraxin 3 boosts innate immune recognition and complement deposition.
Monomeric CRP contributes to complement control in fluid phase and on cellular surfaces and increases phagocytosis by recruiting factor H.
Complement factor H binds at two independent sites to C-reactive protein in acute phase concentrations.
Molecular basis of C-reactive protein binding and modulation of complement activation by factor H-related protein 4.
Both domain 19 and domain 20 of factor H are involved in binding to complement C3b and C3d.
Structural basis for engagement by complement factor H of C3b on a self surface.
Complement factor H binds malondialdehyde epitopes and protects from oxidative stress.
Bivalent and co-operative binding of complement factor H to heparan sulfate and heparin.
Proteomic analysis of microvesicles from plasma of healthy donors reveals high individual variability.
Atypical hemolytic uremic syndrome-associated variants and autoantibodies impair binding of factor h and factor h-related protein 1 to pentraxin 3.
Malaria parasites co-opt human factor H to prevent complement-mediated lysis in the mosquito midgut.
In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
Identification of a Haemophilus influenzae factor H-Binding lipoprotein involved in serum resistance.
Circulating AIM prevents hepatocellular carcinoma through complement activation.
Factor H-related protein 5 interacts with pentraxin 3 and the extracellular matrix and modulates complement activation.
Complement Factor H Binds to Human Serum Apolipoprotein E and Mediates Complement Regulation on High Density Lipoprotein Particles.
Staphylococcus aureus SdrE captures complement factor H's C-terminus via a novel 'close, dock, lock and latch' mechanism for complement evasion.
FHR-1 Binds to C-Reactive Protein and Enhances Rather than Inhibits Complement Activation.
Regulator-dependent mechanisms of C3b processing by factor I allow differentiation of immune responses.
C-reactive protein and pentraxin-3 binding of factor H-like protein 1 differs from complement factor H: implications for retinal inflammation.
Human factor H deficiency. Mutations in framework cysteine residues and block in H protein secretion and intracellular catabolism.
Factor H binds host cell surface markers
Factor I inactivates plasma Factor H-bound C3b
Complement factor I binds to extracellular Factor H:C3b
Complement factor I binds to membrane-associated Factor H:C3b
Factor I inactivates Factor H-boundC3b
Factor H binds to membrane-associated C3b
Mapping of the domains required for decay acceleration activity of the human factor H-like protein 1 and factor H.
Intracellular complement factor H protects neurons during CNS inflammation.
CFH source-specific interaction, ontology and access evidence
Complement factor H regulates retinal development and its absence may establish a footprint for age related macular degeneration.