Gene Ontology annotation through association of InterPro records with GO terms

Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity

Annotation inferences using phylogenetic trees

Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping

Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt

Gene Ontology annotation based on curation of immunofluorescence data

Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara

Electronic Gene Ontology annotations created by ARBA machine learning models

Combined Automated Annotation using Multiple IEA Methods

Specific localization of the guanosine triphosphate (GTP) cyclohydrolase I-immunoreactivity in the human brain.

3' deletions cause aniridia by preventing PAX6 gene expression.

Zinc plays a key role in human and bacterial GTP cyclohydrolase I.

GTP cyclohydrolase I gene transfer augments intracellular tetrahydrobiopterin in human endothelial cells: effects on nitric oxide synthase activity, protein levels and dimerisation.

Role of human GTP cyclohydrolase I and its regulatory protein in tetrahydrobiopterin metabolism.

GTP cyclohydrolase I utilizes metal-free GTP as its substrate.

Cytokine-stimulated GTP cyclohydrolase I expression in endothelial cells requires coordinated activation of nuclear factor-kappaB and Stat1/Stat3.

Augmented BH4 by gene transfer restores nitric oxide synthase function in hyperglycemic human endothelial cells.

The assays of activities and function of TH, AADC, and GCH1 and their potential use in ex vivo gene therapy of PD.

A yeast 2-hybrid analysis of human GTP cyclohydrolase I protein interactions.

GTP cyclohydrolase feedback regulatory protein controls cofactor 6-tetrahydrobiopterin synthesis in the cytosol and in the nucleus of epidermal keratinocytes and melanocytes.

Novel mutations in the guanosine triphosphate cyclohydrolase 1 gene associated with DYT5 dystonia.

Discovery of common human genetic variants of GTP cyclohydrolase 1 (GCH1) governing nitric oxide, autonomic activity, and cardiovascular risk.

Proteomic analysis of GTP cyclohydrolase 1 multiprotein complexes in cultured normal adult human astrocytes under both basal and cytokine-activated conditions.

Critical role for tetrahydrobiopterin recycling by dihydrofolate reductase in regulation of endothelial nitric-oxide synthase coupling: relative importance of the de novo biopterin synthesis versus salvage pathways.

Toward an understanding of the protein interaction network of the human liver.

The neurobiology of tetrahydrobiopterin biosynthesis: a model for regulation of GTP cyclohydrolase I gene transcription within nigrostriatal dopamine neurons.

Purification of GTP cyclohydrolase I from human liver and production of specific monoclonal antibodies.

A reference map of the human binary protein interactome.

A hybrid approach reveals the allosteric regulation of GTP cyclohydrolase I.

Localization of GTP cyclohydrolase I in human peripheral blood smears using a specific monoclonal antibody and an immune-alkaline phosphatase labeling technique.

The application of 8-aminoguanosine triphosphate, a new inhibitor of GTP cyclohydrolase I, to the purification of the enzyme from human liver.

Pteridine biosynthesis in human endothelial cells. Impact on nitric oxide-mediated formation of cyclic GMP.

Characterization of mouse and human GTP cyclohydrolase I genes. Mutations in patients with GTP cyclohydrolase I deficiency.

Hereditary progressive dystonia with marked diurnal fluctuation caused by mutations in the GTP cyclohydrolase I gene.

GTP cyclohydrolase I feedback regulatory protein is a pentamer of identical subunits. Purification, cDNA cloning, and bacterial expression.

Cytokines stimulate GTP cyclohydrolase I gene expression in cultured human umbilical vein endothelial cells.

GCH1 reduces GTP to dihydroneopterin triphosphate

GCHFR binds to GCH1 and negatively regulates its activity

Deep research report on GCH1