Electronic Gene Ontology annotations created by transferring manual GO annotations between related proteins based on shared sequence features
Combined Automated Annotation using Multiple IEA Methods
UniProtKB entry for PSEPK hemH
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HemH inserts ferrous iron into protoporphyrin IX.
"Catalyzes the ferrous insertion into protoporphyrin IX."
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HemH is the sole protoheme-forming step represented by this reaction.
"biosynthesis; protoheme from protoporphyrin-IX: step 1/1."
OpenScientist research report for PSEPK hemH
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The report confirms that its target-specific functional assignment is family-based because no dedicated KT2440 HemH experiment was found.
"No dedicated biochemical or genetic study of the *P. putida* KT2440 HemH protein was found"