Gene Ontology annotation through association of InterPro records with GO terms

Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt

PMID:17437634

The innate immune repertoire in cnidaria--ancestral complexity and stochastic gene loss.

Nematostella has a single MyD88 homologue (NvMyD88) and a single Toll/TLR (NvTLR-1), plus IL-1R-like TIR proteins distinct from MyD88 and TLRs.

PMID:29109290

Sea anemone model has a single Toll-like receptor that can function in pathogen detection, NF-κB signal transduction, and development.

The Nv-TLR TIR domain binds human MAL and MYD88; Nv-TLR activates NEMO-dependent NF-kappaB in human cells and responds to heat-killed Vibrio and flagellin.

PMID:27806695

Insights into the innate immunome of actiniarians using a comparative genomic approach.

Single copies of TLR and MyD88 in actiniarians; MyD88 predicted proteins lack transmembrane domains.

PMID:23112184

MyD88-deficient Hydra reveal an ancient function of TLR signaling in sensing bacterial colonizers.

MyD88 knockdown in Hydra alters bacterial colonisation and increases susceptibility to Pseudomonas aeruginosa.

PMID:29080785

A conserved Toll-like receptor-to-NF-κB signaling pathway in the endangered coral Orbicella faveolata.

PMID:17120026

Rel homology domain-containing transcription factors in the cnidarian Nematostella vectensis.