Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping

Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt

GO_REF:0000107

Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara

GO_REF:0000120

Combined Automated Annotation using Multiple IEA Methods

PMID:1730602

Glycoproteins V and Ib-IX form a noncovalent complex in the platelet membrane.

GPV and GPIb-IX are coprecipitated by monoclonal antibodies demonstrating noncovalent complex formation
Binding studies showed 24,370 GPIb-IX complexes and 11,170 molecules of GPV per platelet

PMID:1939645

von Willebrand factor binding to platelet GpIb initiates signals for platelet activation.

vWF binding to GPIb initiates phospholipase C activation, PKC activation, and calcium mobilization
Anti-GPIb antibodies inhibit these signaling responses

PMID:2771955

Human platelet glycoprotein IX: an adhesive prototype of leucine-rich glycoproteins with flank-center-flank structures.

GPIX is a leucine-rich glycoprotein that is part of the GPIb-IX complex
The GPIb-IX complex functions as the von Willebrand factor receptor
GPIX has type I membrane topology with transmembrane domain

PMID:9432024

Novel point mutation in the leucine-rich motif of the platelet glycoprotein IX associated with Bernard-Soulier syndrome.

GP9 mutations cause Bernard-Soulier syndrome
Mutations in GPIX leucine-rich motif impair surface expression of GPIb-IX-V complex

PMID:10429193

A CD9, alphaIIbbeta3, integrin-associated protein, and GPIb/V/IX complex on the surface of human platelets is influenced by alphaIIbbeta3 conformational states.

GPIb-V-IX forms a complex with CD9, alphaIIb-beta3, and IAP on platelet surface
Complex localized to plasma membrane

PMID:10501658

Platelet glycoprotein Ib: a zinc-dependent binding protein for the heavy chain of high-molecular-weight kininogen.

GPIbalpha binds high-molecular-weight kininogen in zinc-dependent manner
Links GPIb-IX-V complex to intrinsic coagulation pathway

PMID:16293600

The structure of the GPIb-filamin A complex.

Filamin A anchors GPIb-IX-V receptor to actin cytoskeleton
Structure of GPIbalpha-filamin A interaction resolved

PMID:25416956

A proteome-scale map of the human interactome network.

PMID:31515488

Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations.

Reactome:R-HSA-114670

GPIb-IX-V binds to vWF:Collagen complex

Reactome:R-HSA-158145

factor XI + platelet glycoprotein (GP) Ib:IX:V complex -> factor XI:platelet glycoprotein (GP) Ib:IX:V complex

Reactome:R-HSA-158300

factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (XIIa catalyst)

Reactome:R-HSA-158333

factor IX -> factor IXa + factor IX activation peptide (factor XIa catalyst)

Reactome:R-HSA-158419

factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (thrombin catalyst)

Reactome:R-HSA-429529

Thrombin binding to GP1b:IX:V

Reactome:R-HSA-430073

GPIb-IX-V binding to 14-3-3 zeta is reduced by shear stress

Reactome:R-HSA-430076

GP1b-IX-V binds 14-3-3-zeta

Reactome:R-HSA-430096

GP1b-IX-V binds filamin

Reactome:R-HSA-443402

GP1b-IX-V:13-3-3-zeta complexes with p85 PI3K

Reactome:R-HSA-443418

GP1b signaling involves c-Src

Reactome:R-HSA-9673223

FIX(29-461) variant is not activated (factor XIa catalyst)

Reactome:R-HSA-9823065

GPIb:IX:V binds to VWF multimer:collagen

Reactome:R-HSA-9823706

VWF variant does not bind GPIb:IX:V

Reactome:R-HSA-9844251

GP1BA variant binds to VWF multimer:collagen

file:human/GP9/GP9-deep-research-falcon.md

Deep research report on GP9