FAA4 (YMR246W; UniProt P47912) notes
- Long-chain acyl-CoA synthetase; prefers C14:0 and cis-9 monoenes PMID:7650027.
- Redundant with Faa1p for oleoyl-CoA formation, acyl-CoA pools and fatty acid import PMID:11477098.
- Complex with Fat1p PMID:12601005.
- ER in growth, relocalises to LDs in stationary phase PMID:34161133; partial plasma membrane pool, weak LCB transport PMID:27136724.
- Stress granule HDA (PMID:26777405) single proteomic hit, non-core.
Pathway-context observations
- Like FAA1, acts outside peroxisomes; contribution to beta-oxidation indirect (FAO RCA non-core, cytosol RCA over-annotated).