GO_REF:0000033

Annotation inferences using phylogenetic trees

GO_REF:0000044

Gene Ontology annotation based on UniProtKB keywords

GO_REF:0000117

Electronic Gene Ontology annotations created by ARBA machine learning models

GO_REF:0000120

Combined Automated Annotation using Multiple IEA Methods

PMID:23827681

OTU deubiquitinases reveal mechanisms of linkage specificity and enable ubiquitin chain restriction analysis.

OTUD3 is a linkage-specific OTU DUB with preference for K6- and K11-linked polyubiquitin; crystal structure of the OTU domain (residues 52-209).

PMID:26280536

Deubiquitylase OTUD3 regulates PTEN stability and suppresses tumorigenesis.

OTUD3 deubiquitinates and stabilizes PTEN, suppressing PI3K-AKT signaling and tumorigenesis.

PMID:32011234

Distinct regulatory ribosomal ubiquitylation events are reversible and hierarchically organized.

OTUD3 (and USP21) antagonize ZNF598-mediated 40S ribosomal ubiquitylation, deubiquitinating eS10 and limiting RQC activation; Cys76 is the catalytic nucleophile.

PMID:32296183

A reference map of the human binary protein interactome.

PMID:33961781

Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.

PMID:35675826

Deubiquitinase OTUD3 regulates metabolism homeostasis in response to nutritional stresses.

OTUD3 deubiquitinates and stabilizes PPARD in the nucleus to regulate glucose/lipid metabolism and oxidative phosphorylation; glucose/fatty acids drive CBP-dependent acetylation and nuclear translocation.

PMID:38288086

OTUD3 suppresses the mTORC1 signaling by deubiquitinating KPTN.

Reactome:R-HSA-5688426

Reactome: Deubiquitination

Reactome:R-HSA-6807206

Reactome: Ovarian tumor domain proteases

Reactome:R-HSA-8873946

Reactome: Regulation of PTEN stability and activity