hsp-16.1 curation notes

UniProt P34696 (Swiss-Prot) = HSP-16.1/HSP-16.11, encoded by identical genes
hsp-16.1 (T27E4.8) and hsp-16.11 (T27E4.2). Deep research: not run (falcon
timeout; perplexity-lite unavailable).

Gene structure / family

• hsp16-1 and hsp16-48 are head-to-head, duplicated as an inverted repeat PMID:2632349.
• Subclasses: PMID:2632349.

Expression

• Strictly heat-inducible PMID:1550963.
• Hypoxia-responsive (unlike hsp-16.41/48) PMID:15522291.

Function

• Holdase: inferred from paralogue HSP-16.2 PMID:9305934. GO:0140309 rows MODIFY -> NTR holdase chaperone activity (as hsp-16.2).
• Golgi / PMR-1 / heat stroke PMID:22972192. No NEW process added: abstract-only, and the precise role (chaperone of PMR-1 vs regulator) is not established.
• Abeta co-IP of HSP-16s PMID:12089340.
• Immunity requirement (IGI, PMID:16916933) kept as non-core.

Note on protein refolding IBA

hsp-16.2 review REMOVEd this IBA; here KEEP_AS_NON_CORE (sHSPs contribute the
holding step upstream of HSP70 refolding; PAINT node not contradicted).