GO_REF:0000024

Manual transfer of experimentally-verified manual GO annotation data to orthologs using Ensembl Compara

GO_REF:0000033

Annotation inferences using phylogenetic trees

GO_REF:0000044

Gene Ontology annotation through association of InterPro records with GO terms

GO_REF:0000107

Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara

GO_REF:0000117

Electronic Gene Ontology annotations created by ARBA machine learning models

GO_REF:0000120

Combined Automated Annotation using Multiple IEA Methods

PMID:18489706

Auxilin depletion causes self-assembly of clathrin into membraneless cages in vivo.

Auxilin is a cofactor for HSC70-mediated uncoating of clathrin-coated vesicles; depletion of both auxilin isoforms inhibits clathrin-mediated endocytosis and causes formation of nonproductive membraneless clathrin cages.

PMID:20160091

Endocytosis and clathrin-uncoating defects at synapses of auxilin knockout mice.

Auxilin and GAK act as co-chaperones supporting HSC70-dependent clathrin uncoating of clathrin-coated vesicles; auxilin-knockout synapses show increased clathrin-coated vesicles/empty cages and impaired synaptic vesicle endocytosis.

PMID:29735704

LRRK2 phosphorylation of auxilin mediates synaptic defects in dopaminergic neurons from patients with Parkinson's disease.

LRRK2 phosphorylates auxilin in its clathrin-binding domain, altering clathrin binding and disrupting synaptic vesicle endocytosis in PD dopaminergic neurons; auxilin interacts with the clathrin heavy chain CLTC.

Reactome:R-HSA-421836