Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Gene Ontology annotation based on curation of immunofluorescence data
Automatic Gene Ontology annotation based on Rhea mapping
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
Role of common gene variations in the molecular pathogenesis of short-chain acyl-CoA dehydrogenase deficiency.
Novel localization of OCTN1, an organic cation/carnitine transporter, to mammalian mitochondria.
Identification and characterization of new long chain acyl-CoA dehydrogenases.
Proteomic characterization of the human sperm nucleus.
Molecular cloning and nucleotide sequence of complementary DNAs encoding human short chain acyl-coenzyme A dehydrogenase and the study of the molecular basis of human short chain acyl-coenzyme A dehydrogenase deficiency.
Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context.
Purification and properties of short chain acyl-CoA, medium chain acyl-CoA, and isovaleryl-CoA dehydrogenases from human liver.
-
Purified human SCAD dehydrogenates butyryl-CoA to crotonyl-CoA.
"The products of SCA dehydrogenase/butyryl-CoA, MCA dehydrogenase/octanoyl-CoA, and IV dehydrogenase/isovaleryl-CoA reactions were identified as crotonyl-CoA"
-
Purified SCAD binds one FAD per subunit.
"each contains 1 mol of FAD per subunit"
-
Purified SCAD can use ETF as an electron acceptor.
"They all utilized electron transfer flavoprotein (ETF) or phenazine methosulfate (PMS) as an electron acceptor."
Architecture of the human interactome defines protein communities and disease networks.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
Cloning and characterization of the mouse short-chain acyl-CoA dehydrogenase cDNA.
-
SCAD is one of the homologous dehydrogenases catalyzing the first reaction of fatty acid beta-oxidation, with short-chain (C4-C6) acyl-CoA substrates.
"one of five homologous dehydrogenases that catalyze the first reaction in the beta-oxidation of fatty acids"
Butanoyl-CoA+FAD => Crotonoyl-CoA+FADH2
Hexanoyl-CoA+FAD => trans-Hex-2-enoyl-CoA+FADH2
UniProt P16219: Short-chain specific acyl-CoA dehydrogenase, mitochondrial