UMAD1 PN Consistency Notes
- Generated: 2026-06-18
- Project: PROTEOSTASIS
- Scope: PN consistency rereview against local AIGR review and available deep-research artifacts
- UniProt: C9J7I0
- AIGR review status: COMPLETE
- Review batch: proteostasis-pr-1217 (PR 1217)
- Batch change status: added
Source Files Checked
Deep Research Files
- No
*-deep-research*.md file found in this gene directory.
AIGR Review Snapshot
- Description: UMAD1 is a poorly characterized 137 amino acid human protein containing a predicted C-terminal UMA domain. Its name and domain architecture place it in the UBAP1/MVB12-associated UMA-domain protein family, but current local evidence does not establish a specific ESCRT-I complex, endosomal sorting, autophagy, membrane fission, or viral budding function for UMAD1. UniProt lists no FUNCTION comment or GO cross-references for UMAD1, and GOA currently contains only broad IntAct protein-binding evidence from a large-scale binary interactome map.
- Existing/core annotation action counts: MARK_AS_OVER_ANNOTATED: 1
PN Consistency Summary
- Consistency: MAJOR divergence. The PN annotation asserts UMAD1 is "Component of the ESCRT-I complex, involved in autophagosome closure" and projects GO:0000813 + GO:0000045. The review YAML and notes conclude the opposite: UMAD1 is poorly characterized, UniProt has no FUNCTION comment and zero GO/PAN-GO annotations, and the only GOA evidence is generic IPI protein binding (HuRI; GABARAPL1, TH isoform 3). The review explicitly declines any ESCRT-I/autophagy function.
- PN story / NEW pressure: The PN asserts a role (ESCRT-I membership + autophagosome assembly) not in GO and not supported by the review. PMID:32424346 lists UMAD1 only as a possible UMA-domain fourth subunit and notes some theoretical complexes may not form. Verdict: PN over-reaches — neither GO:0000813 nor GO:0000045 is defensible for UMAD1 on current evidence (would be a speculative NEW from name/domain only).
- Evidence alignment: PN cites PMID:32424346 (helical ESCRT-I scaffold). Review cites the same PMID plus PMID:32296183 (HuRI) and UniProt — and reads PMID:32424346 as explicitly NOT establishing a UMAD1 complex. Same papers, opposite conclusions.
- Verdict: CONTRADICTION — PN projects ESCRT-I + autophagosome-assembly membership that the review rejects as unsupported. Recommend the PN leaf not project GO terms onto UMAD1 (mark gene-level no_mapping/UNDECIDED) pending direct evidence.
Full Consistency Review
- UniProt: C9J7I0 · batch: proteostasis-pr-1217 · review status: COMPLETE
- PN placement: ALP
…|Sealing of autophagophore membrane|ESCRT-I complex component ; PN-node mapping: leaf mapped/ok_for_propagation GO:0000813 ESCRT I complex; group mapped GO:0000045 autophagosome assembly (both flagged new_to_goa).
- Consistency: MAJOR divergence. The PN annotation asserts UMAD1 is "Component of the ESCRT-I complex, involved in autophagosome closure" and projects GO:0000813 + GO:0000045. The review YAML and notes conclude the opposite: UMAD1 is poorly characterized, UniProt has no FUNCTION comment and zero GO/PAN-GO annotations, and the only GOA evidence is generic IPI protein binding (HuRI; GABARAPL1, TH isoform 3). The review explicitly declines any ESCRT-I/autophagy function.
- PN story / NEW pressure: The PN asserts a role (ESCRT-I membership + autophagosome assembly) not in GO and not supported by the review. PMID:32424346 lists UMAD1 only as a possible UMA-domain fourth subunit and notes some theoretical complexes may not form. Verdict: PN over-reaches — neither GO:0000813 nor GO:0000045 is defensible for UMAD1 on current evidence (would be a speculative NEW from name/domain only).
- Mapping strategy: This gene should NOT drive the ALP leaf/group projection. UMAD1 is the weakest member of the ESCRT-I-component leaf (cf. UBAP1, VPS28); propagating GO:0000813/GO:0000045 to it on family-name grounds is exactly the kind of paralog/domain over-annotation to avoid.
- Evidence alignment: PN cites PMID:32424346 (helical ESCRT-I scaffold). Review cites the same PMID plus PMID:32296183 (HuRI) and UniProt — and reads PMID:32424346 as explicitly NOT establishing a UMAD1 complex. Same papers, opposite conclusions.
- Verdict: CONTRADICTION — PN projects ESCRT-I + autophagosome-assembly membership that the review rejects as unsupported. Recommend the PN leaf not project GO terms onto UMAD1 (mark gene-level no_mapping/UNDECIDED) pending direct evidence.
PN Dossier Context
- review_batch: proteostasis-pr-1217
- review_yaml: genes/human/UMAD1/UMAD1-ai-review.yaml
- PN workbook rows: 1
PN row 1: Autophagy-Lysosome Pathway | Autophagosome closure maturation and lysosome fusion | Sealing of autophagophore membrane | ESCRT-I complex component
- UniProt: C9J7I0
- In branches: ALP
- Notes: Component of the ESCRT-I complex, involved in autophagosome closure
- PN references (titles):
- A helical assembly of human ESCRT-I scaffolds reverse-topology membrane scission | Nature Structural & Molecular Biology
- PN-node mapping records (path + ancestors):
- [type] Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Sealing of autophagophore membrane|ESCRT-I complex component
status=mapped scope=ok_for_propagation_to_go GO=[GO:0000813 ESCRT I complex]
rationale: This leaf is restricted to ESCRT-I components used in autophagophore sealing. The shared GO assertion is ESCRT I complex membership.
- [group] Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Sealing of autophagophore membrane
status=mapped scope=ok_for_propagation_to_go GO=[GO:0000045 autophagosome assembly]
rationale: This group captures autophagophore closure/sealing, a late step in autophagosome assembly. Autophagosome assembly is the safer process target than autophagosome-lysosome fusion.
- [class] Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion
status=context_only scope=too_broad_to_propagate GO=[GO:0016236 macroautophagy]
rationale: This class is a late macroautophagy context, but the subtree mixes docking, fusion, localization, membrane-composition, and unknown late-stage roles. The class-level relation is useful for display while propagation is restricted to narrower mechanism nodes.
- [branch] Autophagy-Lysosome Pathway
status=no_mapping scope= GO=[]
rationale: Reviewed as the top-level PN branch. It is a project taxonomy umbrella rather than a direct GO assertion; all propagation must come from manually curated child nodes.
Projected GO annotations (2)
- GO:0000045 autophagosome assembly | scope=ok_for_propagation_to_go | goa_status=new_to_goa | from=Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Sealing of autophagophore membrane
- GO:0000813 ESCRT I complex | scope=ok_for_propagation_to_go | goa_status=new_to_goa | from=Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Sealing of autophagophore membrane|ESCRT-I complex component
Note
This file is generated from the current PROTEOSTASIS phase-1 dossier and local gene-review artifacts. Edit the source review, PN mapping, or dossier rather than this generated note when correcting the underlying curation.