Falcon deep research report for HSPA1A
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Gene Ontology annotation based on curation of immunofluorescence data
Automatic assignment of GO terms using logical inference, based on on inter-ontology links
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
Control of mRNA decay by heat shock-ubiquitin-proteasome pathway.
Crystal structure and activity of human p23, a heat shock protein 90 co-chaperone.
Chaperone hsp27 inhibits translation during heat shock by binding eIF4G and facilitating dissociation of cap-initiation complexes.
HSP90, HSP70, and GAPDH directly interact with the cytoplasmic domain of macrophage scavenger receptors.
CHIP is associated with Parkin, a gene responsible for familial Parkinson's disease, and enhances its ubiquitin ligase activity.
Cofactor Tpr2 combines two TPR domains and a J domain to regulate the Hsp70/Hsp90 chaperone system.
BAG5 inhibits parkin and enhances dopaminergic neuron degeneration.
Heat shock protein 70 inhibits alpha-synuclein fibril formation via preferential binding to prefibrillar species.
TRIM37 defective in mulibrey nanism is a novel RING finger ubiquitin E3 ligase.
Proteomics of human umbilical vein endothelial cells applied to etoposide-induced apoptosis.
Histone deacetylase 8 safeguards the human ever-shorter telomeres 1B (hEST1B) protein from ubiquitin-mediated degradation.
Hsp70 regulates erythropoiesis by preventing caspase-3-mediated cleavage of GATA-1.
HDJC9, a novel human type C DnaJ/HSP40 member interacts with and cochaperones HSP70 through the J domain.
Molecular composition of IMP1 ribonucleoprotein granules.
Endogenous signals released from necrotic cells augment inflammatory responses to bacterial endotoxin.
Cellular cofactors affecting hepatitis C virus infection and replication.
Structural basis for the cooperation of Hsp70 and Hsp110 chaperones in protein folding.
Characterization of the human COP9 signalosome complex using affinity purification and mass spectrometry.
Interactions between Hsp70 and the hydrophobic core of alpha-synuclein inhibit fibril assembly.
Characterization of exosome-like vesicles released from human tracheobronchial ciliated epithelium: a possible role in innate defense.
Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT).
MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis.
HSP72 protects cells from ER stress-induced apoptosis via enhancement of IRE1alpha-XBP1 signaling through a physical interaction.
Genome-wide YFP fluorescence complementation screen identifies new regulators for telomere signaling in human cells.
ChChd3, an inner mitochondrial membrane protein, is essential for maintaining crista integrity and mitochondrial function.
The diverse members of the mammalian HSP70 machine show distinct chaperone-like activities.
Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation.
Intrinsically disordered proteins as molecular shields.
The C-terminal helices of heat shock protein 70 are essential for J-domain binding and ATPase activation.
Proteomic analysis of microvesicles from plasma of healthy donors reveals high individual variability.
Nucleophosmin (NPM1/B23) interacts with activating transcription factor 5 (ATF5) protein and promotes proteasome- and caspase-dependent ATF5 degradation in hepatocellular carcinoma cells.
Insights into RNA biology from an atlas of mammalian mRNA-binding proteins.
The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.
A newly uncovered group of distantly related lysine methyltransferases preferentially interact with molecular chaperones to regulate their activity.
In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
Identification and characterization of a novel human methyltransferase modulating Hsp70 protein function through lysine methylation.
Stress-induced localization of HSPA6 (HSP70B') and HSPA1A (HSP70-1) proteins to centrioles in human neuronal cells.
The role of oxidative stress in Parkinson's disease.
Binding of human nucleotide exchange factors to heat shock protein 70 (Hsp70) generates functionally distinct complexes in vitro.
Discovery of multiple interacting partners of gankyrin, a proteasomal chaperone and an oncoprotein--evidence for a common hot spot site at the interface and its functional relevance.
Mutations in the substrate binding site of human heat-shock protein 70 indicate specific interaction with HLA-DR outside the peptide binding groove.
Hsp70 and Hsp90 oppositely regulate TGF-β signaling through CHIP/Stub1.
The molecular chaperone HSP70 binds to and stabilizes NOD2, an important protein involved in Crohn disease.
RING finger protein RNF207, a novel regulator of cardiac excitation.
E-cadherin interactome complexity and robustness resolved by quantitative proteomics.
Tag7 (PGLYRP1) in Complex with Hsp70 Induces Alternative Cytotoxic Processes in Tumor Cells via TNFR1 Receptor.
A novel nuclear DnaJ protein, DNAJC8, can suppress the formation of spinocerebellar ataxia 3 polyglutamine aggregation in a J-domain independent manner.
HSP70 regulates the function of mitotic centrosomes.
ARD1-mediated Hsp70 acetylation balances stress-induced protein refolding and degradation.
HSP70-Hrd1 axis precludes the oncorepressor potential of N-terminal misfolded Blimp-1s in lymphoma cells.
Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains.
Evidence for a role of Hsp70 in the regulation of the heat shock response in mammalian cells.
Molecular chaperones as HSF1-specific transcriptional repressors.
Inhibition of cellular proliferation by the Wilms tumor suppressor WT1 requires association with the inducible chaperone Hsp70.
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand
STIP1(HOP) binds HSP90 and HSP70:HSP40:nascent protein
HSF1 acetylation at Lys80
HSP70 binds to HSP40:nascent protein
AUF1 binds translation and heat shock proteins
AUF1 (hnRNP D0) is ubiquitinylated
HSF1-mediated gene expression
Acetylated HSF1 dissociates from DNA
HSP40s activate intrinsic ATPase activity of HSP70s in the nucleoplasm
HSP40s activate intrinsic ATPase activity of HSP70s in the cytosol
NPC transports Hikeshi:HSP70s:ATP from cytosol to nucleoplasm
HSP110s exchange ATP for ADP on HSP70s:ADP
FKBP4 binds HSP90:ATP:STIP1:HSP70:nascent protein
p23 (PTGES3) binds HSP90:ATP:FKBP5:nascent protein
FKBP5 binds HSP90:ATP:STIP1:HSP70:nascent protein
ATP binding to HSP90 triggers conformation change
p23 (PTGES3) binds HSP90:ATP:FKBP4:nascent protein
Exocytosis of ficolin-rich granule lumen proteins
FA core complex:HSP70s binds PKR
Oxidized DNAJA1 binds HSPA1A,B (HSP70) displacing HSF1