Annotation inferences using phylogenetic trees
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PANTHER phylogenetic annotations propagate conserved ABRAXAS2/ABRO1 family localization, microtubule, ubiquitin-chain binding, and mitotic spindle terms.
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping
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UniProt subcellular-location keyword mapping supports broad nucleus, cytoplasm, cytoskeleton, and spindle-pole cellular component annotations.
Gene Ontology annotation based on curation of immunofluorescence data
K63-specific deubiquitination by two JAMM/MPN+ complexes: BRISC-associated Brcc36 and proteasomal Poh1.
NBA1, a new player in the Brca1 A complex, is required for DNA damage resistance and checkpoint control.
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The BRCA1-A complex study supports polyubiquitin-chain binding by related complex components, but its direct evidence is for BRCA1-A/ABRAXAS1 rather than ABRAXAS2/BRISC.
"four members of the BRCA1-A complex possess a polyubiquitin chain-binding capability"
Defining the human deubiquitinating enzyme interaction landscape.
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Proteomic interactome mapping places ABRAXAS2 among DUB-associated interaction data but does not by itself define an informative GO molecular function beyond generic protein binding.
"We identified 774 candidate interacting proteins associated with 75 Dubs."
The Lys63-specific deubiquitinating enzyme BRCC36 is regulated by two scaffold proteins localizing in different subcellular compartments.
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KIAA0157/ABRAXAS2 is a cytosolic scaffold that activates BRCC36 in the BRISC complex and distinguishes BRISC from nuclear BRCA1-A.
"KIAA0157 mainly localizes in cytosol and activates BRCC36 in the cytoplasm."
Regulation of Abro1/KIAA0157 during myocardial infarction and cell death reveals a novel cardioprotective mechanism for Lys63-specific deubiquitination.
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ABRO1 is induced in myocardial ischemia/reperfusion and contributes to cardioprotection through K63-linked deubiquitination.
"Reducing the Abro1 protein level exacerbated cellular damage and cell death of cardiomyocytes due to MI/R injury."
NBA1/MERIT40 and BRE interaction is required for the integrity of two distinct deubiquitinating enzyme BRCC36-containing complexes.
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ABRO1-containing BRISC is mainly cytoplasmic, lacks the BRCA1-interacting motif, and does not interact with BRCA1.
"Because it lacks the BRCA1-interacting motif, the ABRO1 complex does not interact with BRCA1."
ATF4 interacts with Abro1/KIAA0157 scaffold protein and participates in a cytoprotective pathway.
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ABRO1 can enter the nucleus during cellular stress and interact with ATF4 in a cytoprotective pathway.
"Abro1 is predominantly cytoplasmic, but during cellular stress it enters the nucleus and co-localizes with ATF4."
A BRISC-SHMT complex deubiquitinates IFNAR1 and regulates interferon responses.
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SHMT2 targets BRISC to K63-ubiquitinated IFNAR1, promoting receptor deubiquitination and type I interferon responses.
"SHMT directs BRISC activity at K63-Ub chains conjugated to the type 1 interferon (IFN) receptor chain 1 (IFNAR1)."
ABRO1 suppresses tumourigenesis and regulates the DNA damage response by stabilizing p53.
The deubiquitinating enzyme complex BRISC is required for proper mitotic spindle assembly in mammalian cells.
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BRISC localizes to microtubule minus ends and spindle poles, binds microtubules, and promotes spindle assembly by deubiquitinating NUMA.
"BRISC is a microtubule (MT)-associated protein complex that predominantly localizes to the minus ends of K-fibers and spindle poles and directly binds to MTs"
Metabolic control of BRISC-SHMT2 assembly regulates immune signalling.
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PLP-dependent SHMT2 oligomerization regulates BRISC-SHMT2 assembly and type I interferon signaling.
"Mutations in BRISC that disrupt SHMT2 binding impair type I interferon signalling in response to inflammatory stimuli."
Structural Basis of BRCC36 Function in DNA Repair and Immune Regulation.
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Structures distinguish ABRAXAS/BRCA1-A DNA-repair targeting from ABRO1/BRISC immune-stress signaling and SHMT2 regulation.
"The BRCA1-A and BRISC complexes serve in DNA double-strand break repair and immune signaling"
A reference map of the human binary protein interactome.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
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Proteome-scale AP-MS interaction data support generic interaction evidence but not a specific ABRAXAS2 molecular function.
"Dual proteome-scale networks reveal cell-specific remodeling of the human interactome."
Quantitative fragmentomics allow affinity mapping of interactomes.
AI-guided pipeline for protein-protein interaction drug discovery identifies a SARS-CoV-2 inhibitor.
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A preprint interactome/drug-discovery pipeline reports generic interaction evidence that is not an informative ABRAXAS2 GO function.
"AI-guided pipeline for protein-protein interaction drug discovery identifies a SARS-CoV-2 inhibitor."
BRISC complex deubiquitinates NLRP3
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Reactome places ABRO1/FAM175B in cytosolic BRISC-mediated K63 deubiquitination of NLRP3.
"FAM175B (ABRO1), another BRISC subunit, binds directly to NLRP3 leading to FAM175B-dependent recruitment of the BRISC complex"
ABRAXAS2 Falcon deep research report