Gene Ontology annotation through association of InterPro records with GO terms

Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity

Annotation inferences using phylogenetic trees

Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt

Gene Ontology annotation based on curation of immunofluorescence data

Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara

Electronic Gene Ontology annotations created by ARBA machine learning models

Combined Automated Annotation using Multiple IEA Methods

Missense mutations interfere with VEGFR-3 signalling in primary lymphoedema.

Isolated lymphatic endothelial cells transduce growth, survival and migratory signals via the VEGF-C/D receptor VEGFR-3.

Direct recruitment of CRK and GRB2 to VEGFR-3 induces proliferation, migration, and survival of endothelial cells through the activation of ERK, AKT, and JNK pathways.

Vascular endothelial growth factor receptor-3 and focal adhesion kinase bind and suppress apoptosis in breast cancer cells.

The VEGF-C/Flt-4 axis promotes invasion and metastasis of cancer cells.

Autocrine loop between vascular endothelial growth factor (VEGF)-C and VEGF receptor-3 positively regulates tumor-associated lymphangiogenesis in oral squamoid cancer cells.

VEGF receptor 2/-3 heterodimers detected in situ by proximity ligation on angiogenic sprouts.

Ephrin-B2 controls VEGF-induced angiogenesis and lymphangiogenesis.

Protein tyrosine phosphatase PTPN14 is a regulator of lymphatic function and choanal development in humans.

Effective suppression of vascular network formation by combination of antibodies blocking VEGFR ligand binding and receptor dimerization.

Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition.

Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins.

Structural and mechanistic insights into VEGF receptor 3 ligand binding and activation.

Carbohydrate-binding protein CLEC14A regulates VEGFR-2- and VEGFR-3-dependent signals during angiogenesis and lymphangiogenesis.

A Human IgSF Cell-Surface Interactome Reveals a Complex Network of Protein-Protein Interactions.

Physical and functional interactome atlas of human receptor tyrosine kinases.

Mutation at tyrosine residue 1337 abrogates ligand-dependent transforming capacity of the FLT4 receptor.

Biochemical characterization of two isoforms of FLT4, a VEGF receptor-related tyrosine kinase.

The FLT4 gene encodes a transmembrane tyrosine kinase related to the vascular endothelial growth factor receptor.

VEGF-C receptor binding and pattern of expression with VEGFR-3 suggests a role in lymphatic vascular development.

Vascular endothelial growth factor D (VEGF-D) is a ligand for the tyrosine kinases VEGF receptor 2 (Flk1) and VEGF receptor 3 (Flt4).

VEGF-C,D bind to VEGFR3 leading to receptor dimerization

FLT4 gene expression is stimulated by Notch4

Novel splice variants derived from the receptor tyrosine kinase superfamily are potential therapeutics for rheumatoid arthritis.

Blocking VEGFR-3 suppresses angiogenic sprouting and vascular network formation.

ALK1 signaling regulates early postnatal lymphatic vessel development.

Claudin-like protein 24 interacts with the VEGFR-2 and VEGFR-3 pathways and regulates lymphatic vessel development.

VEGFR-3 ligand-binding and kinase activity are required for lymphangiogenesis but not for angiogenesis.

Cardiovascular failure in mouse embryos deficient in VEGF receptor-3.

FLT4 source evidence and assay-scope guide

FLT4 annotation review notes