Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniPathway vocabulary mapping
Gene Ontology annotation based on curation of immunofluorescence data
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Combined Automated Annotation using Multiple IEA Methods
Evidence for a structural mutation (347Ala to Thr) in a German family with 3-ketothiolase deficiency.
Crystallographic and kinetic studies of human mitochondrial acetoacetyl-CoA thiolase: the importance of potassium and chloride ions for its structure and function.
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High-resolution crystal structures of human T2 (apo and CoA complex, with/without K+). Defines the homotetramer, the CoA- and K+-binding sites near the catalytic site, and K+ activation.
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T2 is important for synthesis and degradation of ketone bodies and for degradation of 2-methylacetoacetyl-CoA; it uniquely accepts 2-methyl-branched acetoacetyl-CoA and degrades acetoacetyl-CoA and 2-methylacetoacetyl-CoA with similar catalytic efficiencies.
Large-scale proteomics and phosphoproteomics of urinary exosomes.
Molecular cloning and sequence of the complementary DNA encoding human mitochondrial acetoacetyl-coenzyme A thiolase and study of the variant enzymes in cultured fibroblasts from patients with 3-ketothiolase deficiency.
In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
Cholesterol 25-Hydroxylase inhibits SARS-CoV-2 and other coronaviruses by depleting membrane cholesterol.
Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context.
Molecular, biochemical, and clinical characterization of mitochondrial acetoacetyl-coenzyme A thiolase deficiency in two further patients.
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Characterized 3KTD alleles (N158D, T297M, A301P); expression analyses showed reduced/abolished T2 activity, with only T297M retaining detectable residual activity.
Molecular studies of mitochondrial acetoacetyl-coenzyme A thiolase deficiency in the two original families.
Characterization of N93S, I312T, and A333P missense mutations in two Japanese families with mitochondrial acetoacetyl-CoA thiolase deficiency.
Tetrameric Acetyl-CoA Acetyltransferase 1 Is Important for Tumor Growth.
alpha-methylacetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA
2 acetyl-CoA <=> acetoacetyl-CoA + CoA
acetoacetyl-CoA + CoA <=> 2 acetyl-CoA
CLPXP binds mitochondrial matrix proteins
LONP1 degrades mitochondrial matrix proteins
LONP1 binds mitochondrial matrix proteins
CLPXP degrades mitochondrial matrix proteins
ACAT1 tetramer acetylates IDH2 dimer
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Reactome reaction capturing the moonlighting protein-lysine-acetyltransferase activity of the ACAT1 homotetramer (acetylation of IDH2 at K413), localized to the mitochondrial matrix. Used here as a matrix-localization annotation; the acetyltransferase activity itself is not in the curated GOA MF set under review.
Identification of the CoA-modified forms of mitochondrial acetyl-CoA acetyltransferase and of glutamate dehydrogenase as nearest-neighbour proteins.
Circulating glucose, insulin and ketone bodies and enzymes of ketone body utilization in brain mitochondria from suckling rats treated with high L-thyroxine doses.
Glycemia, ketonemia, and brain enzymes of ketone body utilization in suckling and adult rats undernourished from intrauterine life.
The course of ketosis and the activity of key enzymes of ketogenesis and ketone-body utilization during development of the postnatal rat.
Evidence for an in vivo modification of mitochondrial proteins by coenzyme A.