Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt.
Novel genes for potential ligand-binding proteins in subregions of the olfactory mucosa.
Update of the human secretoglobin (SCGB) gene superfamily and an example of 'evolutionary bloom' of androgen-binding protein genes within the mouse Scgb gene superfamily.
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SCGB1C1 localizes to Bowman's glands in the olfactory mucosa and is thought
to act as an odorant-binding protein with small hydrophobic ligands.
"SCGB1C1 has been shown to be localised to Bowman's glands in the olfactory mucosa. Here, it is thought to act as an odorant-binding protein, with ligands appearing to be small, hydrophobic molecules"
SCGB1C1 Plays a Critical Role in Suppression of Allergic Airway Inflammation through the Induction of Regulatory T Cell Expansion.
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In an OVA-induced mouse asthma model, intranasal recombinant SCGB1C1
suppressed airway hyperresponsiveness, eosinophilic inflammation, goblet
cell hyperplasia, and serum IgE, decreased IL-5/IL-4, increased IL-10/TGF-beta,
and expanded CD4+CD25+Foxp3+ regulatory T cells. This is the strongest
functional evidence for SCGB1C1, but it is in mouse, not human.
"The intranasal administration of SCGB1C1 significantly inhibited AHR, the presence of eosinophils in BALF, eosinophilic inflammation, goblet cell hyperplasia in the lung, and serum total and allergen-specific IgE."
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SCGB1C1 treatment increased regulatory T cell populations and shifted the
cytokine balance toward regulatory/anti-inflammatory programs.
"SCGB1C1 treatment notably increased the populations of CD4+CD25+Foxp3+ regulatory T cells (Tregs) in asthmatic mice."
Deep research on SCGB1C1 function
The cytokine-driven regulation of secretoglobins in normal human upper airway and their expression, particularly that of uteroglobin-related protein 1, in chronic rhinosinusitis.
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In ex vivo cultured normal human nasal mucosa, SCGB1C1 (RYD5) is cytokine
responsive: IFN-gamma down-regulates it while the Th2 cytokines IL-4 and
IL-13 up-regulate it; IL-1beta and TNF-alpha have no significant effect.
This links SCGB1C1 expression to the type 2 vs type 1 cytokine milieu in
human upper airway.
"IFN-γ down-regulated and IL-4 and IL-13 up-regulated its expression; however, no significant effect was observed for IL-1β and TNF-α"
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SCGB1C1 (RYD5) transcript was specifically increased in CRSwNP (nasal
polyposis), differing significantly from CRSsNP, suggesting involvement in
polyp-associated epithelial programs rather than a defined molecular mechanism.
"SCGB1C1 (RYD5) was only increased, whereas the expression of SCGB3A1 (UGRP2) was only decreased, in CRSwNP, and there was a significant difference between CRSsNP and CRSwNP"
Secretoglobins in the big picture of immunoregulation in airway diseases.
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Secretoglobins are secreted by barrier-organ epithelia and are embedded in
immunoregulatory and anti-inflammatory processes of airway diseases,
functioning as elements of innate immune control at epithelial barriers.
Mechanistic detail (receptors, signaling) for individual SCGBs including
SCGB1C1 remains limited.
"The proteins of the secretoglobin (SCGB) family are expressed by secretory tissues of barrier organs. They are embedded in immunoregulatory and anti-inflammatory processes of airway diseases."
Falcon (Edison) deep research report on SCGB1C1 function and GO annotation
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Synthesis of retrieved literature treats SCGB1C1/RYD5 as a secreted mucosal
protein with two plausible, non-exclusive roles: binding/transport of
hydrophobic ligands/odorants in the olfactory environment, and
immunomodulatory/innate-defense functions in airway mucosa. Receptors and
downstream signaling for secretoglobins remain poorly characterized.
"SCGB1C1 is a **secreted mucosal protein** with two plausible, non-exclusive roles"
UniProt record for SCGB1C1 (Q8TD33)