TMED10 (TMP21/p23/p24delta) notes

Deep research providers unavailable (no API keys). Notes from UniProt P49755 and cached literature.

Identity / topology

• TMED10, a type I single-pass membrane protein of the p24/emp24/gp25L family. Signal peptide 1-31, lumenal
  GOLD domain (32-185), TM 186-206, short cytoplasmic tail 207-219 with COPI/COPII-binding motifs.
• [UniProt P49755 "Cargo receptor involved in protein vesicular trafficking and quality control in the endoplasmic reticulum (ER) and Golgi"]; cycles between ER, ERGIC and Golgi, binding COPI and COPII coats.
• Localization conclusion: early secretory pathway - ER, ERGIC and (cis-)Golgi membranes and COPI/COPII
  transport vesicles. It is NOT a plasma-membrane-resident protein (PM annotations are ortholog ISS/IEA; its
  PM link is that it chaperones certain GPCRs to the surface, not that it resides there).

Function

• p24-family cargo receptor: incorporates secretory cargo (notably GPI-anchored proteins, with TMED2) into
  COPII vesicles at the lumenal side and participates in COPI vesicle coat formation; primary receptor for
  ARF1-GDP on Golgi membranes.
• [UniProt "may also act as a protein channel after oligomerization, facilitating the post-translational entry of leaderless cytoplasmic cargo into the ERGIC"] - the TMED10-channeled unconventional protein secretion (UPS) pathway for IL-1beta etc. PMID:32272059.
• Component of the presenilin/gamma-secretase complex (TMP21), modulating gamma-secretase activity PMID:16641999.