Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Gene Ontology annotation based on curation of immunofluorescence data
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Combined Automated Annotation using Multiple IEA Methods
Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration.
Cloning of three novel neuronal Cdk5 activator binding proteins.
Identification of a common protein association region in the neuronal Cdk5 activator.
The cyclin-dependent kinase 5 activators p35 and p39 interact with the alpha-subunit of Ca2+/calmodulin-dependent protein kinase II and alpha-actinin-1 in a calcium-dependent manner.
Identification of a novel, membrane-associated neuronal kinase, cyclin-dependent kinase 5/p35-regulated kinase.
Apoptosis-associated tyrosine kinase is a Cdk5 activator p35 binding protein.
Mechanism of CDK5/p25 binding by CDK inhibitors.
Defining Cdk5 ligand chemical space with small molecule inhibitors of tau phosphorylation.
Microtubule association of the neuronal p35 activator of Cdk5.
Roles of heat-shock protein 90 in maintaining and facilitating the neurodegenerative phenotype in tauopathies.
Myristoylation of p39 and p35 is a determinant of cytoplasmic or nuclear localization of active cyclin-dependent kinase 5 complexes.
No difference in kinetics of tau or histone phosphorylation by CDK5/p25 versus CDK5/p35 in vitro.
Cyclin-dependent kinase 5 modulates the transcriptional activity of the mineralocorticoid receptor and regulates expression of brain-derived neurotrophic factor.
Phosphorylation of glutamyl-prolyl tRNA synthetase by cyclin-dependent kinase 5 dictates transcript-selective translational control.
Cdk5-mediated phosphorylation of endophilin B1 is required for induced autophagy in models of Parkinson's disease.
Ubiquitin C-terminal hydrolase L1 (UCH-L1) acts as a novel potentiator of cyclin-dependent kinases to enhance cell proliferation independently of its hydrolase activity.
The protein interaction landscape of the human CMGC kinase group.
A proteome-scale map of the human interactome network.
Architecture of the human interactome defines protein communities and disease networks.
Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
An isoform of the neuronal cyclin-dependent kinase 5 (Cdk5) activator.
p35 is a neural-specific regulatory subunit of cyclin-dependent kinase 5.
Phosphorylation of CRMPs by Cdk5
Phosphorylation of CRMPs by GSK3beta
p25-bound CDK5 phosphorylates CDC25B
p25-bound CDK5 phosphorylates CDC25C
p25-bound CDK5 phosphorylates CDC25A
CDK5:p25 translocates to the nucleus
EGR1-dependent CDK5R1 gene expression
UniProtKB record for human CDK5R1