LPD1 notes (YFL018C, P09624)

• E3 dihydrolipoyl dehydrogenase, EC 1.8.1.4, FAD homodimer [PMID:2821168 "The LPD1 gene of S. cerevisiae, which encodes lipoamide dehydrogenase (EC 1.8.1.4), has been cloned and characterized"; UniProt:P09624].
• Shared E3 of PDH, KGDH and GCS: PMID:3528755; PMID:7498764.
• KGDH recruitment by Kgd4 PMID:25165143; free pool in matrix PMID:25165143.
• Branched-chain 2-oxoacid DH activity Lpd1-dependent PMID:1479341; E1/E2 partners unknown (no clear BCKDH orthologues).
• ROS source PMID:17110466.

Curation observations

• IMP 'enables' GO:0004375 (P-protein) and GO:0004591 (E1 of KGDH) -> MODIFY to GO:0004148; whole-complex phenotypes mis-assigned as subunit MF.
• protein binding (Kgd2, Kgd4) x6 -> REMOVE; captured by complex membership.
• RCA cytosol (GLYCLEAV-PWY, PYRUVDEHYD-PWY) -> REMOVE.

2026-11-10 glycine cleavage module completion pass (Claude, AI-assisted)

• Every row now carries a verbatim supporting quote; truncated UniProt quotes were completed to the end of the claim.
• Broad parent rows shared across the module's P/H/T/L reviews were harmonized: glycine metabolic/catabolic process (and amino acid metabolic process) -> MODIFY to GO:0019464; for the L proteins 2-oxoglutarate metabolic process and tricarboxylic acid cycle -> MODIFY to GO:0120551, generic oxidoreductase parents -> MODIFY to GO:0004148, FAD binding ACCEPT.