TARDBP notes

2026-11-03 ORGANELLES batch 4 (mitochondrion rows)

• Rows: GO:0005739 IEA (GO_REF:0000044, SL-0173). No sub-compartment rows. Action stays KEEP_AS_NON_CORE; reason extended and supported_by added.
• UniProt: Mitochondrion {ECO:0000269|PubMed:28794432, PubMed:33031745}; [file:human/TARDBP/TARDBP-uniprot.txt "A small subset localizes in mitochondria (PubMed:28794432)"]. Mapping sound. Both papers fetched 2026-11-03 (full text).
• Protease protection: PMID:28794432, plus immuno-EM inside mitochondria. UV-CLIP binds mt-tRNAs (Asn, Gln, Pro) and processing intermediates, a matrix-side function.
• Import: depends on the TIM22 carrier pathway and AGK PMID:33031745; that paper cites earlier work PMID:33031745.
• Outcome: root only. The internal pool is real (minor), but the lines disagree on matrix vs inner membrane, the protease assay cannot separate matrix from IMS or inner membrane, and there is no presequence, so neither GO:0005759 nor GO:0005743 is added. Candidate for a sub-mitochondrial fractionation (alkaline carbonate, digitonin titration) to decide.