Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Gene Ontology annotation based on curation of immunofluorescence data
Automatic assignment of GO terms using logical inference, based on inter-ontology links
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
Molecular cloning of integrin-associated protein: an immunoglobulin family member with multiple membrane-spanning domains implicated in alpha v beta 3-dependent ligand binding.
Isolation and characterization of CD47 glycoprotein: a multispanning membrane protein which is the same as integrin-associated protein (IAP) and the ovarian tumour marker OA3.
Rh-related antigen CD47 is the signal-transducer integrin-associated protein
Integrin-associated protein is a receptor for the C-terminal domain of thrombospondin
A CD9, alphaIIbbeta3, integrin-associated protein, and GPIb/V/IX complex on the surface of human platelets is influenced by alphaIIbbeta3 conformational states.
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CD47 is in complex with integrins on platelets
"A noncovalently associated complex comprising of CD9, the fibrinogen (Fg) receptor alphaIIbbeta3, integrin-associated protein (IAP), and glycoprotein (GP) Ib/V/IX complex was isolated from Chaps-solubilized human platelets"
Bidirectional negative regulation of human T and dendritic cells by CD47 and its cognate receptor signal-regulator protein-alpha: down-regulation of IL-12 responsiveness and inhibition of dendritic cell activation.
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CD47-SIRPalpha interaction is a negative regulatory pathway
"CD47 on T cells and its cognate receptor SIRP-alpha on DC define a novel regulatory pathway that may be involved in the maintenance of homeostasis by preventing the escalation of the inflammatory immune response"
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Inhibits dendritic cell maturation and cytokine production
"SIRP-alpha engagement by CD47-Fc prevents the phenotypic and functional maturation of immature DC and still inhibits cytokine production by mature DC"
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Down-regulates IL-12 responsiveness of T cells
"CD47 ligation by CD47 mAb or L-SIRP-alpha transfectants inhibits IL-12R expression and down-regulates IL-12 responsiveness of activated CD4(+) and CD8(+) adult T cells"
Adhesion of human T cells to antigen-presenting cells through SIRPbeta2-CD47 interaction costimulates T-cell proliferation.
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SIRPbeta2/gamma binds CD47
"Here, we show that SIRPbeta2 is expressed on T cells and activated natural killer (NK) cells and, like SIRPalpha, binds CD47, mediating cell-cell adhesion"
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Mediates cell-cell adhesion
"SIRPbeta2 is expressed on T cells and activated natural killer (NK) cells and, like SIRPalpha, binds CD47, mediating cell-cell adhesion"
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Costimulates T cell proliferation
"engagement of SIRPbeta2 on T cells by CD47 on antigen-presenting cells results in enhanced antigen-specific T-cell proliferation"
Insulin-like growth factor binding protein-5 (IGFBP-5) interacts with thrombospondin-1 to induce negative regulatory effects on IGF-I actions.
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IGFBP-5 modulates TSP1-CD47 interactions
"IGFBP-5 inhibits the binding of TS-1 to IAP, and this results in an alteration of the ability of TS-1 to modulate the disruption of the IAP/SHPS-1 interaction"
CD47 augments Fas/CD95-mediated apoptosis
Functional elements on SIRPalpha IgV domain mediate cell surface binding to CD47
Differential interactions of thrombospondin-1, -2, and -4 with CD47 and effects on cGMP signaling and ischemic injury responses.
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TSP1 binds CD47 with highest affinity
"high affinity interaction with CD47 appears to be relatively specific for the signature domain of TSP1"
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Affects cGMP signaling
"Thrombospondin-1 regulates nitric oxide (NO) signaling in vascular cells via CD47"
Myelin down-regulates myelin phagocytosis by microglia and macrophages through interactions between CD47 on myelin and SIRPα (signal regulatory protein-α) on phagocytes.
Integrin-associated protein (CD47) is a putative mediator for soluble fibrinogen interaction with human red blood cells membrane.
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CD47 mediates fibrinogen-RBC interaction
"Our results support a specific and age-dependent interaction of soluble fibrinogen with human RBC membrane; additionally we present CD47 as a putative mediator in this process"
CR1-mediated ATP release by human red blood cells promotes CR1 clustering and modulates the immune transfer process.
Inflammation-induced proteolytic processing of the SIRPα cytoplasmic ITIM in neutrophils propagates a proinflammatory state.
A proteome-scale map of the human interactome network.
SIRP/CD47 signaling in neurological disorders
CD47 Promotes Age-Associated Deterioration in Angiogenesis, Blood Flow and Glucose Homeostasis.
A Human IgSF Cell-Surface Interactome Reveals a Complex Network of Protein-Protein Interactions.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
A physical wiring diagram for the human immune system.
COMP binds Integrin alpha5beta1, Integrin alphaVbeta3, CD47
p-4Y-SIRPA:CD47:SKAP2 binds FYB
p-4Y-SIRPA:CD47 binds PTK2B
p-4Y-SIRPA:CD47 binds GRB2-1
p-4Y-SIRPA:CD47 binds SKAP2
Exocytosis of tertiary granule membrane proteins
Exocytosis of specific granule membrane proteins
Deep research report on CD47