Deep research report on FGFR2 function, signaling, and clinical relevance
-
FGFR2 is a plasma membrane receptor tyrosine kinase with Ig-like extracellular domains whose IIIb/IIIc isoform switching determines epithelial vs mesenchymal ligand specificity.
-
Core signaling through FRS2/MAPK and PLCgamma pathways drives proliferation, differentiation, and branching morphogenesis in lungs, limbs, skeleton, and glands.
Gene Ontology annotation through association of InterPro records with GO terms
Gene Ontology annotation based on Enzyme Commission mapping
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
Structural interactions of fibroblast growth factor receptor with its ligands.
Crystal structures of two FGF-FGFR complexes reveal the determinants of ligand-receptor specificity.
Structural basis for fibroblast growth factor receptor 2 activation in Apert syndrome.
Structural basis by which alternative splicing confers specificity in fibroblast growth factor receptors.
Determination of ligand-binding specificity by alternative splicing: two distinct growth factor receptors encoded by a single gene.
A novel form of fibroblast growth factor receptor 2. Alternative splicing of the third immunoglobulin-like domain confers ligand binding specificity.
Cbl-mediated degradation of Lyn and Fyn induced by constitutive fibroblast growth factor receptor-2 activation supports osteoblast differentiation.
Tyrosine 769 of the keratinocyte growth factor receptor is required for receptor signaling but not endocytosis.
FGF-10 and its receptor exhibit bidirectional paracrine targeting to urothelial and smooth muscle cells in the lower urinary tract.
Intracellular retention, degradation, and signaling of glycosylation-deficient FGFR2 and craniosynostosis syndrome-associated FGFR2C278F.
Cloning and expression of two distinct high-affinity receptors cross-reacting with acidic and basic fibroblast growth factors.
Translocation of fibroblast growth factor-10 and its receptor into nuclei of human urothelial cells.
Heparanase cleavage of perlecan heparan sulfate modulates FGF10 activity during ex vivo submandibular gland branching morphogenesis.
MiR-125b, a microRNA downregulated in psoriasis, modulates keratinocyte proliferation by targeting FGFR2.
Inhibition of basal FGF receptor signaling by dimeric Grb2.
Molecular mechanism of SSR128129E, an extracellularly acting, small-molecule, allosteric inhibitor of FGF receptor signaling.
Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network.
Long-Pentraxin 3 Derivative as a Small-Molecule FGF Trap for Cancer Therapy.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
Physical and functional interactome atlas of human receptor tyrosine kinases.
A physical wiring diagram for the human immune system.
Jackson-Weiss and Crouzon syndromes are allelic with mutations in fibroblast growth factor receptor 2.
Mutations in the fibroblast growth factor receptor 2 gene cause Crouzon syndrome.
Activation of fibroblast growth factor (FGF) receptors by recombinant human FGF-5.
Receptor specificity of the fibroblast growth factor family.
[Nucleotide sequences at intron 6 and exon 7 junction of fibroblast growth factor receptor 2 and rapid mutational analysis in Apert syndrome].
PI3K-containing complexes phosphorylate PIP2 to PIP3
Autocatalytic phosphorylation of FGFR2b
Autocatalytic phosphorylation of FGFR2c
Dimerization of FGFR2 ligand-independent mutants
Autocatalytic phosphorylation of FGFR2 ligand-independent mutants
Dimerization of overexpressed FGFR2
Autocatalytic phosphorylation of overexpressed FGFR2 variants
Tyrosine kinase inhibitors bind to overexpressed FGFR2 variants
FGFR2c mutants bind an expanded range of ligands
FGFR2b mutants bind an expanded range of ligands
Dimerization of FGFR2 point mutants with enhanced kinase activity
Autocatalytic phosphorylation of FGFR2c mutants with enhanced ligand binding
Autocatalytic phosphorylation of FGFR2b mutants with enhanced ligand binding
Autocatalytic phosphorylation of FGFR2 point mutants with enhanced kinase activity
GP369 inhibits activation of amplified FGFR2 signaling
Point mutants of FGFR2 bind and are inactivated by tyrosine kinase inhibitors
PI3K phosphorylates PIP2 to PIP3
PI3K inhibitors block PI3K catalytic activity
Activated FGFR2 phosphorylates PLCG1
p-4Y-PLCG1 dissociates from activated FGFR2
Activated FGFR2 binds PLCG1
Activated FGFR2 phosphorylates FRS2
Activated FGFR2 binds FRS2
Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
Activated FGFR2 binds SHC1
Activated FGFR2:p-SHC1 binds GRB2:SOS1
Activated FGFR2 phosphorylates SHC1
Activated ERK1/2 threonine-phosphorylates FGFR2-associated FRS2
Activated FGFR2 binds FRS3
Activated FGFR2 phosphorylates FRS3
Activated FGFR2 phosphorylates PPTN11
Activated FGFR2:p-FRS bind to PPTN11
Activated FGFR2:p-FRS2 binds GRB2:GAB1:PIK3R1
Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
Activated FGFR2:pFRS binds GRB2:SOS1
Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
Activated FGFR2:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1
Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
CBL ubiquitinates FRS2 and FGFR2
FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
FGFR2-associated PI3K phosphorylates PIP2 to PIP3
p-CBL:GRB2 binds p-FRS2:activated FGFR2
p-4Y-PLCG1 dissociates from activated FGFR2 mutants
Activated FGFR2 mutants:p-FRS2 binds GRB2-SOS1
Activated FGFR2 mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
Activated FGFR2 mutants:p-FRS2:GRB2:GAB1:PIK3R1 binds PIK3CA
Activated FGFR2 mutants phosphorylate FRS2
Activated FGFR2 mutants phosphorylate PLCG1
Activated FGFR2 mutants:p-FRS2 binds GRB2:GAB1:PIK3R1
Activated FGFR2 mutant-associated PI3K phosphorylates PIP2 to PIP3
Activated FGFR2 mutants bind FRS2
Activated FGFR2 mutants bind PLCG1
RAS GEFs promote RAS nucleotide exchange
FGFR2 fusions autophosphorylate
Mouse FGFR2 IIIa TM binds FGF1,2 and full-length receptors