Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Gene Ontology annotation based on curation of immunofluorescence data
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
ATR and ATRIP: partners in checkpoint signaling.
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ATRIP and ATR are mutually dependent checkpoint partners.
"Thus, ATRIP and ATR are mutually dependent partners in cell cycle checkpoint signaling pathways."
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ATR and ATRIP localize to damage foci.
"ATR and ATRIP both localize to intranuclear foci after DNA damage or inhibition of replication."
MSH2 and ATR form a signaling module and regulate two branches of the damage response to DNA methylation.
Reconstitution of a human ATR-mediated checkpoint response to damaged DNA.
Functional genomic screens identify CINP as a genome maintenance protein.
Reconstitution of RPA-covered single-stranded DNA-activated ATR-Chk1 signaling.
Cyclin-dependent kinase 9-cyclin K functions in the replication stress response.
Identification of the first ATRIP-deficient patient and novel mutations in ATR define a clinical spectrum for ATR-ATRIP Seckel Syndrome.
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Compound-heterozygous ATRIP mutations cause ATR-ATRIP Seckel syndrome.
"A nonsense mutational change in one ATRIP allele results in a C-terminal truncated protein, which impairs ATR-ATRIP interaction; the other allele is abnormally spliced."
PRP19 transforms into a sensor of RPA-ssDNA after DNA damage and drives ATR activation via a ubiquitin-mediated circuitry.
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PRP19 promotes ATRIP accumulation at damage sites.
"PRP19 facilitates the accumulation of ATRIP, the regulatory partner of the ataxia telangiectasia mutated and Rad3-related (ATR) kinase, at DNA damage sites."
A proteome-scale map of the human interactome network.
A mitosis-specific and R loop-driven ATR pathway promotes faithful chromosome segregation.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
Recruitment and activation of Chk1
Binding of ATR-ATRIP to the RPA-ssDNA complex
Binding of ATR:ATRIP to RPA at resected DNA DSBs
CHEK1 is recruited to resected DNA DSBs
Activation of CHEK1 at resected DNA DSBs
ATR activation at DNA DSBs
RAD52 promotes single strand annealing at resected DNA DSBs
ERCC1:XPF cleaves flaps generated by SSA
RAD51 binds BRCA2 at resected DNA DSBs
Association of RAD51 with RAD52:DNA double-strand break ends
Association of RAD52 with the RPA complex at resected DNA DSBs
The complex of ATR and ATRIP is recruited to ICL-DNA
ATR phosphorylates RPA2, FANCI, FANCD2 and FANCM at ICL-DNA
BRCA2 mutants with BRC defects or a defect in the C-terminal RAD51 binding site do not bind RAD51
ERCC1:XPF binds DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps generated by SSA
Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes.
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ATRIP binding to RPA-ssDNA recruits ATR-ATRIP to DNA.
"The binding of ATRIP to RPA-coated ssDNA enables the ATR-ATRIP complex to associate with DNA and stimulates phosphorylation of the Rad17 protein that is bound to DNA."
TopBP1 activates ATR through ATRIP and a PIKK regulatory domain.
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ATRIP's TopBP1-interacting region is needed for ATR activation.
"Here, we show that ATRIP contains a TopBP1-interacting region that is necessary for the association of TopBP1 and ATR, for TopBP1-mediated activation of ATR, and for cells to survive and recover DNA synthesis following replication stress."
UniProt entry Q8WXE1 (ATRIP_HUMAN)
Affinage mechanistic annotation for ATRIP (human)