Gene Ontology annotation through association of InterPro records with GO terms

Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity

Annotation inferences using phylogenetic trees

Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt

Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara

Electronic Gene Ontology annotations created by ARBA machine learning models

Combined Automated Annotation using Multiple IEA Methods

ErbB2 and ErbB3 receptors mediate inhibition of calcium-dependent chloride secretion in colonic epithelial cells.

Heterodimerization of the epidermal-growth-factor (EGF) receptor and ErbB2 and the affinity of EGF binding are regulated by different mechanisms.

Crystal structure of the complex of human epidermal growth factor and receptor extracellular domains.

EGF activates its receptor by removing interactions that autoinhibit ectodomain dimerization.

Epigen, the last ligand of ErbB receptors, reveals intricate relationships between affinity and mitogenicity.

Activation of TRAP/mediator subunit TRAP220/Med1 is regulated by mitogen-activated protein kinase-dependent phosphorylation.

Human colostrum: identification of minor proteins in the aqueous phase by proteomics.

Growth factor regulation of hyaluronan synthesis and degradation in human dermal fibroblasts: importance of hyaluronan for the mitogenic response of PDGF-BB.

Ligand-induced structural transitions in ErbB receptor extracellular domains.

Integral and associated lysosomal membrane proteins.

IQGAP1 integrates Ca2+/calmodulin and B-Raf signaling.

BCAR3 regulates EGF-induced DNA synthesis in normal human breast MCF-12A cells.

Large-scale proteomics and phosphoproteomics of urinary exosomes.

Cell-cell contact formation governs Ca2+ signaling by TRPC4 in the vascular endothelium: evidence for a regulatory TRPC4-beta-catenin interaction.

Epidermal growth factor receptor regulates beta-catenin location, stability, and transcriptional activity in oral cancer.

Epidermal growth factor's activation of Ras is inhibited by four cardiac hormones.

The chemokine receptor CXCR7 is highly expressed in human glioma cells and mediates antiapoptotic effects.

Comprehensive analysis of low-abundance proteins in human urinary exosomes using peptide ligand library technology, peptide OFFGEL fractionation and nanoHPLC-chip-MS/MS.

Engineered epidermal growth factor mutants with faster binding on-rates correlate with enhanced receptor activation.

Simultaneous visualization of the extracellular and cytoplasmic domains of the epidermal growth factor receptor.

The Ankrd 13 family of UIM-bearing proteins regulates EGF receptor endocytosis from the plasma membrane.

Diacylglycerol kinase θ counteracts protein kinase C-mediated inactivation of the EGF receptor.

In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.

Inhibition of tumor angiogenesis and growth by a small-molecule multi-FGF receptor blocker with allosteric properties.

Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network.

Navigator-3, a modulator of cell migration, may act as a suppressor of breast cancer progression.

Secreted and O-GlcNAcylated MIF binds to the human EGF receptor and inhibits its activation.

Functional independence of the epidermal growth factor receptor from a domain required for ligand-induced internalization and calcium regulation.

EGFR Ligands Differentially Stabilize Receptor Dimers to Specify Signaling Kinetics.

Insights into the structure and dynamics of lysyl oxidase propeptide, a flexible protein with numerous partners.

The S100A4 Protein Signals through the ErbB4 Receptor to Promote Neuronal Survival.

PI3Kδ as a Novel Therapeutic Target in Pathological Angiogenesis.

A reference map of the human binary protein interactome.

Human epidermal growth factor precursor: cDNA sequence, expression in vitro and gene organization.

Three distinct IL-2 signaling pathways mediated by bcl-2, c-myc, and lck cooperate in hematopoietic cell proliferation.

Activation of HER4 by heparin-binding EGF-like growth factor stimulates chemotaxis but not proliferation.

Nerve growth factor regulation of m4 muscarinic receptor mRNA stability but not gene transcription requires mitogen-activated protein kinase activity.

Trans-autophosphorylation of activated ligand-responsive EGFR mutant dimers

Non-covalent tyrosine kinase inhibitors bind and inactivate sensitive ligand-responsive EGFR cancer mutants

Covalent tyrosine kinase inhibitors bind and inactivate EGFR kinase domain mutant dimers resistant to non-covalent tyrosine kinase inhibitors

Binding of EGF to ligand-responsive EGFR mutants

EGF-induced dimerization of ligand-responsive EGFR mutants

Binding of SHC1 to p-6Y-EGFR mutants

Binding of CBL to ligand-responsive p-6Y-EGFR mutants

Binding of GRB2:SOS1 complex to phosphorylated ligand-responsive EGFR mutants

SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with ligand-responsive p-6Y-EGFR mutants)

Phosphorylation of SHC1 by ligand-responsive p-6Y-EGFR mutants

Inefficient ubiquitination of ligand-responsive p-6Y-EGFR mutants by p-Y371-CBL

SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with phosphorylated SHC1 and ligand-responsive p-6Y-EGFR mutants)

Phosphorylation of CBL by ligand-responsive p-6Y-EGFR mutants

Phosphorylated SHC1 in complex with ligand-responsive p-6Y-EGFR mutants recruits GRB2:SOS1 complex

Covalent tyrosine kinase inhibitors bind and inhibit wild-type EGF:EGFR dimers

Binding of PI3K to complex of GRB2:GAB1 and ligand-responsive p-6Y-EGFR mutants

Conversion of PIP2 to PIP3 by PI3K bound to ligand-responsive p-6Y-EGFR mutants

Binding of GRB2:GAB1 complex to ligand-responsive p-6Y-EGFR mutants

PLCG1 binds to ligand-responsive p-6Y-EGFR mutants

Dissociation of phosphorylated PLCG1 from ligand-responsive p-6Y-EGFR mutants

Phosphorylation of PLCG1 by ligand-responsive p-6Y-EGFR mutants

SHC1 phosphorylation by ERBB2 heterodimers

PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR

Binding of GRB2:GAB1 to p-ERBB2:p-EGFR

Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR

EGFR dimerization

Sustained activation of SRC kinase by SHP2

Dephosphorylation of Gab1 by SHP2

SHC1 binds to the phosphorylated EGF receptor:ligand complex

Dephosphorylation of PAG by SHP2

PI3K binds to EGF:EGFR:GRB2:GAB1

GAB1 phosphorylation by EGFR kinase

SHC1 phosphorylation by phosphorylated EGFR

EGFR autophosphorylation

SHP2 dephosphorylates Tyr 992 on EGFR

GRB2:SOS1 binds to phosphorylated SHC1 in complex with EGFR

Phosphorylation of EGFR by SRC kinase

SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1)

PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3)

GRB2:GAB1 binds to phosphorylated EGFR

EGFR binds EGF ligand

GRB2:SOS1 complex binds to EGF:EGFR complex

Activation of SHP2 through the binding to phospho-Gab1

SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1)

Phosphorylation of CBL (EGFR:CBL)

CBL-mediated ubiquitination of CIN85

Sprouty sequesters CBL away from active EGFR

Ubiquitination of stimulated EGFR (CBL)

Assembly of EGFR complex in clathrin-coated vesicles

Beta-Pix:CDC42:GTP binds CBL in EGF:p-6Y-EGFR:CBL:CIN85

Ubiquitination of stimulated EGFR (CBL:GRB2)

CBL ubiquitinates Sprouty

Binding of CBL to EGFR

Phosphorylation of CBL (EGFR:GRB2:CBL)

Localization of CBL:GRB2 to the membrane

EGFR non-clathrin mediated endocytosis

CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix

CBL binds and ubiquitinates phosphorylated Sprouty

MATK (CSK homologous kinase) binds phosphorylated ERBB2

Trans-autophosphorylation of p-Y877-ERBB2 heterodimers

Trans-autophosphorylation of ERBB2 heterodimers

SRC family kinases phosphorylate ERBB2

ERBB2 forms heterodimers with ligand-activated ERBB receptors: EGFR, ERBB3 and ERBB4

ERBB4 forms heterodimers with EGFR

Phospholipase C-gamma1 binds to the activated EGF receptor

EGFR activates PLC-gamma1 by phosphorylation

Active PLC-gamma1 dissociates from EGFR

PI3K phosphorylates PIP2 to PIP3

PI3K inhibitors block PI3K catalytic activity

Exocytosis of platelet alpha granule contents

EGFRvIII cancer variant does not bind EGF ligand

RAS GEFs promote RAS nucleotide exchange

Phosphorylated ERBB2 heterodimers bind MEMO1

MEMO1 binds RHOA:GTP:DIAPH1

Activated ERBB2 binds PTK6 (BRK)

ERBB2 promotes PTK6 autophosphorylation

PTPN12 dephosphorylates ERBB2 on tyrosine Y1248

PTPN12 dephosphorylates EGFR at Y1172 (Y1148)

PTPN18 binds ERBB2:EGFR heterodimers

PTPN18 dephosphorylates ERBB2 at Y1196, Y1112 and Y1248

Epsin family proteins bind ubiquitinated cargo

EGFR phosphorylates EPS15

EGFR binds EPS15, EPN1, EPS15L1

PTPN3 dephosphorylates EPS15

F- and N- BAR domain proteins bind the clathrin-coated pit

CLASP proteins and cargo are recruited to the nascent clathrin-coated pit

Clathrin recruits PIK3C2A

Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2

SNX9 recruits components of the actin polymerizing machinery

BAR domain proteins recruit dynamin

SYNJ hydrolyze PI(4,5)P2 to PI(4)P

Endophilins recruit synaptojanins to the clathrin-coated pit

HSPA8-mediated ATP hydrolysis promotes vesicle uncoating

Clathrin recruits auxilins to the clathrin-coated vesicle

Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle

Dynamin-mediated GTP hydrolysis promotes vesicle scission

Dissociation of clathrin-associated proteins

Dissociation of AAK1 and dephosphorylation of AP-2 mu2

RAB5 and GAPVD1 bind AP-2

CIN85 dissociates from EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85

EGFR phosphorylates NOTCH3

NOTCH3 binds activated EGFR

PTK2 binds activated EGFR

PTK2 autophosphorylates downstream of EGFR

ERBB2 KD mutants heterodimerize

ERBB2 KD mutants trans-autophosphorylate

Phosphorylated heterodimers of ERBB2 KD mutants and EGFR bind GRB2:GAB1

Phosphorylated heterodimers of ERBB2 KD mutants and EGFR, in complex with GRB2:GAB1, bind PI3K

PI3K bound to phosphorylated heterodimers of ERBB2 KD mutants and EGFR converts PIP2 to PIP3

Phosphorylated heterodimers of ERBB2 KD mutants bind SHC1

Phosphorylated heterodimers of ERBB2 KD mutants phosphorylate SHC1

Phosphorylated heterodimers of ERBB2 KD mutants recruit GRB2:SOS1 through SHC1

RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 KD mutants

Phosphorylated heterodimers of ERBB2 KD mutants and EGFR bind GRB2:SOS1

RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 KD mutants and EGFR

Phosphorylated heterodimers of ERBB2 KD mutants and EGFR phosphorylate PLCG1

Phosphorylated heterodimers of ERBB2 KD mutants and EGFR bind PLCG1

ERBB2 ECD mutants heterodimerize with EGFR

Heterodimers of ERBB2 ECD mutants and EGFR trans-autophosphorylate

RAS guanyl nucleotide exchange mediated by the p-6Y- ERBB2 ECD mutants:EGF:p-6Y-EGFR:p-SHC1:GRB2:SOS1

Phosphorylated heterodimers of ERBB2 ECD mutants and EGFR phosphorylate SHC1

PI3K bound to phosphorylated heterodimers of ERBB2 ECD mutants and EGFR converts PIP2 to PIP3

RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 ECD mutants and EGFR through GRB2

GRB2:SOS1 binds to phosphorylated heterodimers of ERBB2 ECD mutants and EGFR

Phosphorylated heterodimers of ERBB2 ECD mutants and EGFR bind PLCG1

Phosphorylated heterodimers of ERBB2 ECD mutants and EGFR phosphorylate PLCG1

Phosphorylated heterodimers of ERBB2 ECD mutants and EGFR recruit GRB2:SOS1 through SHC1

Phosphorylated heterodimers of ERBB2 ECD mutants and EGFR, in complex with GRB2:GAB1, bind PI3K

Phosphorylated heterodimers of ERBB2 ECD mutants and EGFR bind SHC1

Phosphorylated heterodimers of ERBB2 ECD mutants and EGFR bind GRB2:GAB1

ERBB2 TMD/JMD mutants hetrodimerize

Phosphorylated heterodimers of ERBB2 TMD/JMD mutants and EGFR bind GRB2:SOS1

Phosphorylated heterodimers of ERBB2 TMD/JMD mutants recruit GRB2:SOS1 through SHC1

RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 TMD/JMD mutants

Phosphorylated ERBB2 TMD/JMD heterodimers bind SHC1

Phosphorylated heterodimers of ERBB2 TMD/JMD mutants and EGFR phosphorylate PLCG1

Phosphorylated heterodimers of ERBB2 TMD/JMD mutants phosphorylate SHC1

Phosphorylated heterodimers of ERBB2 TMD/JMD mutants and EGFR bind PLCG1

RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 TMD/JMD mutants and EGFR

ERBB2 TMD/JMD heterodimers trans-autophosphorylate

NFE2L2 dependent EGF expression

Shc1 binds phosphorylated ERBB2:EGFR heterodimers

Plcg1 binds P-ERBB2:P-EGFR

Plcg1 phosphorylation by P-ERBB2:P-EGFR