The scaffold protein EPG-7 links cargo-receptor complexes with the autophagic assembly machinery.
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EPG-7 functions as scaffold mediating autophagic degradation of SQST-1 aggregates
"epg-7 functions as a scaffold protein mediating autophagic degradation of several protein aggregates, including aggregates of the p62 homologue SQST-1"
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SQST-1 directly interacts with EPG-7 by co-immunoprecipitation
"SQST-1 was specifically coimmunoprecipitated by anti–EPG-7, but not by control IgG"
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SQST-1 colocalizes with EPG-7 aggregates in autophagy mutants
"SQST-1 directly interacts with EPG-7 and colocalizes with EPG-7 aggregates in autophagy mutants"
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Mutations in epg-7 impair association of SQST-1 aggregates with LGG-1 puncta
"Mutations in epg-7 impair association of SQST-1 aggregates with LGG-1/Atg8 puncta"
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SQST-1 is the C. elegans p62 homologue
"aggregates of the p62 homologue SQST-1"