Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Gene Ontology annotation based on curation of immunofluorescence data
Electronic Gene Ontology annotations created by ARBA machine learning models
Abi-2, a novel SH3-containing protein interacts with the c-Abl tyrosine kinase and modulates c-Abl transforming activity.
Identification of ArgBP1, an Arg protein tyrosine kinase binding protein that is the human homologue of a CNS-specific Xenopus gene.
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ABI2 (ArgBP1) was identified as an Arg kinase binding protein containing SH3 domain, PEST sequences, and proline-rich region. The SH3 domain binds Arg C-terminal SH3-binding site, and N-terminal proline-rich sequence binds Arg SH3 domain. Cytoplasmic localization was demonstrated by immunostaining.
The Abl interactor proteins localize to sites of actin polymerization at the tips of lamellipodia and filopodia.
In search of a function for the E3B1/Abi2/Argbp1/NESH family (Review).
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Review describing ABI family members as adaptor proteins involved in cytoskeletal reorganization, membrane ruffling, lamellipodia formation, and cell migration.
Screen and identification of proteins interacting with ADAM19 cytoplasmic tail.
ABI2-deficient mice exhibit defective cell migration, aberrant dendritic spine morphogenesis, and deficits in learning and memory.
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ABI2 knockout mice show defective cell migration, aberrant dendritic spine morphogenesis, and impaired learning and memory. ABI2 localizes to lamellipodia and nascent adherens junctions. Required for adherens junction assembly.
Towards a proteome-scale map of the human protein-protein interaction network.
NESH (Abi-3) is present in the Abi/WAVE complex but does not promote c-Abl-mediated phosphorylation.
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ABI2, like ABI1, promotes c-Abl-mediated phosphorylation of Mena and WAVE2. ABI2 is present in the Abi/WAVE complex. In contrast, ABI3 (NESH) does not promote c-Abl-mediated phosphorylation due to reduced c-Abl binding.
Tripartite motif protein 32 facilitates cell growth and migration via degradation of Abl-interactor 2.
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TRIM32 directly binds ABI2 and mediates its ubiquitination and proteasomal degradation. TRIM32 overexpression promotes ABI2 degradation, enhancing cell growth, transformation, and motility.
High levels of structural disorder in scaffold proteins as exemplified by a novel neuronal protein, CASK-interactive protein1.
Structure and control of the actin regulatory WAVE complex.
Next-generation sequencing to generate interactome datasets.
Local F-actin network links synapse formation and axon branching.
A proteome-scale map of the human interactome network.
Mapping autosomal recessive intellectual disability - combined microarray and exome sequencing identifies 26 novel candidate genes in 192 consanguineous families.
An interactome perturbation framework prioritizes damaging missense mutations for developmental disorders.
Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
GRAF1 integrates PINK1-Parkin signaling and actin dynamics to mediate cardiac mitochondrial homeostasis.
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ABI2 was identified as a GRAF1-interacting protein enriched in phosphorylated GRAF1 immunoprecipitates. GRAF1 depletion reduced ABI2:WAVE2 complex formation and recruitment of WAVE2 complex (WAVE2, ABI2, CYFIP1) to damaged mitochondria. ABI2 recruits WAVE2 to promote Arp2/3-dependent branched actin remodeling necessary for mitochondrial clearance.
Multimodal cell maps as a foundation for structural and functional genomics.
ABI2 deep research report (Falcon)