Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
MICAL, a novel CasL interacting molecule, associates with vimentin.
Atrophin-1-interacting protein 4/human Itch is a ubiquitin E3 ligase for human enhancer of filamentation 1 in transforming growth factor-beta signaling pathways.
Deregulation of HEF1 impairs M-phase progression by disrupting the RhoA activation cycle.
Structural insights into the association between BCAR3 and Cas family members, an atypical complex implicated in anti-oestrogen resistance.
SHP-2 inhibits tyrosine phosphorylation of Cas-L and regulates cell migration.
Next-generation sequencing to generate interactome datasets.
Abl family kinases modulate T cell-mediated inflammation and chemokine-induced migration through the adaptor HEF1 and the GTPase Rap1.
NEDD9 regulates actin dynamics through cortactin deacetylation in an AURKA/HDAC6-dependent manner.
A proteome-scale map of the human interactome network.
Architecture of the human interactome defines protein communities and disease networks.
Phosphorylation of human enhancer filamentation 1 (HEF1) stimulates interaction with Polo-like kinase 1 leading to HEF1 localization to focal adhesions.
NEDD9 targets COL3A1 to promote endothelial fibrosis and pulmonary arterial hypertension.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
Tyrosine phosphorylation of Crk-associated substrates by focal adhesion kinase. A putative mechanism for the integrin-mediated tyrosine phosphorylation of Crk-associated substrates.
Cell cycle-regulated processing of HEF1 to multiple protein forms differentially targeted to multiple subcellular compartments.
Human enhancer of filamentation 1, a novel p130cas-like docking protein, associates with focal adhesion kinase and induces pseudohyphal growth in Saccharomyces cerevisiae.
Gene Ontology annotation based on curation of immunofluorescence data
Annotation inferences using phylogenetic trees
Combined Automated Annotation using Multiple IEA Methods
A novel Cas family member, HEPL, regulates FAK and cell spreading.
HEF1-dependent Aurora A activation induces disassembly of the primary cilium.
The focal adhesion scaffolding protein HEF1 regulates activation of the Aurora-A and Nek2 kinases at the centrosome.
The hematopoietic isoform of Cas-Hef1-associated signal transducer regulates chemokine-induced inside-out signaling and T cell trafficking.