Krtap29-1 (mouse) review notes

Family-batched review of mammalian keratin-associated proteins (KRTAPs). No deep-research report was generated for this gene; evidence comes from UniProt, cached PubMed records and family reviews.

Family-level evidence

• KAPs form the matrix cross-linking hair keratin IFs PMID:16382671
• PMID:22298953
• Mammal-specific family PMID:18721477
• HGT function less clear PMID:23791804

Gene-specific notes

• Krtap29-1 is PE 3 (inferred from homology), with no FUNCTION text in UniProt and only a genome-assembly reference (PMID:19468303). All annotations in this review are family-level inferences; the MODIFY replacements of the ND rows are therefore lower-confidence than for the transcript-supported KAPs.

Curation decisions

• MF: GO:0030281 structural constituent of cutaneous appendage (OLS-verified; child of GO:0005198). ND root and IEA structural molecule activity rows refined to it.
• CC: GO:0045095 keratin filament (ACCEPT/NEW/MODIFY of ND root).
• BP: GO:0031424 keratinization; hair cycle/follicle development not used (KAPs are downstream structural products).
• No cytosol row in this gene's GOA (family convention where present: KEEP_AS_NON_CORE, synthesized in the cytoplasm but acting in the keratin matrix).
• ISO identical protein binding (HuRI Y2H donors): MARK_AS_OVER_ANNOTATED.
• No bare GO:0005515 rows in this gene's GOA.