Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
Tyrosine phosphorylation-independent nuclear translocation of a dictyostelium STAT in response to DIF signaling.
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STATc (Dd-STATc) regulates the speed of early development and the timing of terminal differentiation and acts as a repressor directing graded ecmA expression among prestalk cell populations.
"Dd-STATc also functions as a repressor, which directs graded expression of the ecmA gene in different prestalk cell populations"
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STATc is tyrosine phosphorylated, dimerizes and translocates to the nucleus upon DIF exposure, but SH2-phosphotyrosine interaction is not required for its DIF-induced nuclear translocation.
"Dd-STATc is tyrosine phosphorylated, dimerizes, and translocates to the nucleus when cells are exposed to DIF"
OSBPa, a predicted oxysterol binding protein of Dictyostelium, is required for regulated entry into culmination.
The Dictyostelium prestalk cell inducer DIF regulates nuclear accumulation of a STAT protein by controlling its rate of export from the nucleus.
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DIF controls STATc nuclear accumulation by inhibiting its CRM1-dependent nuclear export.
"Dd-STATc becomes tyrosine phosphorylated, dimerises and accumulates in the nuclei of Dictyostelium cells exposed to DIF"
A STAT-regulated, stress-induced signalling pathway in Dictyostelium.
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Hyperosmotic stress, heat shock and oxidative stress activate STATc, which then functions as a transcriptional activator of stress-response genes.
"hyperosmotic stress, heat shock and oxidative stress also activate Dd-STATc"
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Osmotic-stress induction of the target genes gapA and rtoA is entirely dependent on STATc.
"Osmotic stress induction of gapA and rtoA is entirely dependent on Dd-STATc"
STATc is a key regulator of the transcriptional response to hyperosmotic shock.
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Approximately 20% of hyperosmotically regulated genes depend on STATc, making it a major regulator of the osmotic stress transcriptome.
"Approximately 20% of the differentially regulated genes were dependent on the presence of STATc"
Evidence that DIF-1 and hyper-osmotic stress activate a Dictyostelium STAT by inhibiting a specific protein tyrosine phosphatase.
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The protein tyrosine phosphatase PTP3 directly binds STATc and dephosphorylates it; DIF-1 and osmotic stress activate STATc by inhibiting PTP3.
"the protein tyrosine phosphatase PTP3 interacts directly with STATc"
Identification of the kinase that activates a nonmetazoan STAT gives insights into the evolution of phosphotyrosine-SH2 domain signaling.
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The tyrosine-kinase-like enzyme Pyk2 phosphorylates STATc on Tyr922 and forms a constitutive complex with STATc via its SH2 domain.
"Pyk2 phosphorylates STATc on Tyr922 in vitro and complexes with STATc both in vitro and in vivo"
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Dictyostelium lacks metazoan tyrosine kinase orthologs; TKL enzymes substitute for JAK-like STATc activation.
"There are no orthologs of the animal tyrosine kinases, but there are very many tyrosine kinase-like kinases (TKLs)"
The calcineurin dependent transcription factor TacA is involved in development and the stress response of Dictyostelium discoideum.
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STATc mediates a well-known Dictyostelium stress response pathway, distinct from the calcineurin/TacA pathway.
"TacA is involved in the stress response of D. discoideum during development in a separate pathway to the well-known stress response in Dictyostelium via STATc"
The arrestin-domain containing protein AdcA is a response element to stress.
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STATc-dependent transcription is required for the timely dephosphorylation of the stress element AdcA.
"STATc-dependent transcriptional activity is involved for the timely dephosphorylation of AdcA in"
Identification of the protein kinases Pyk3 and Phg2 as regulators of the STATc-mediated response to hyperosmolarity.
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The STATc stress pathway includes a positive feedback loop upregulating STATc and STATc-regulated genes; Pyk3 and Phg2 modulate STATc phosphorylation.
"The STATc stress signalling pathway feeds back on itself by upregulating the expression of STATc and STATc-regulated genes"
Two Dictyostelium tyrosine kinase-like kinases function in parallel, stress-induced STAT activation pathways.
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Pyk2 and Pyk3 redundantly phosphorylate STATc; their autophosphorylation sites bind the STATc SH2 domain to enable further kinase action.
"The site(s) that are generated bind the SH2 domain of STATc, and then STATc becomes the target of further kinase action"
The Dictyostelium prestalk inducer differentiation-inducing factor-1 (DIF-1) triggers unexpectedly complex global phosphorylation changes.
Leaps and lulls in the developmental transcriptome of Dictyostelium discoideum.
Dd-STATb, a Dictyostelium STAT protein with a highly aberrant SH2 domain, functions as a regulator of gene expression during growth and early development.
Immune-like phagocyte activity in the social amoeba.
Social amoebae trap and kill bacteria by casting DNA nets.
Dual regulation of a Dictyostelium STAT by cGMP and Ca2+ signalling.
AIGR Gene Hypothesis Deep Research — Dictyostelium discoideum statC (Q54BD4)
PTHR11801 PAINT ancestral annotations