HNRNPC notes

Deep research (falcon) attempted 2026-10-10 and failed (timeout); manual literature review.

• (C1)3C2 tetramer binds 230-240 nt and nucleates 40S hnRNP particles PMID:8264621.
• Molecular ruler sorting Pol II transcripts to mRNA vs snRNA export PMID:22461616.
• Competes with U2AF65 to suppress cryptic Alu exons PMID:23374342.
• m6A-switch enhances HNRNPC binding and affects splicing PMID:25719671 — indirect, structural; m6A reader IDA kept as non-core.
• 3'-UTR poly(U) binding/stabilisation of uPAR mRNA PMID:16010978.
• DNA roles: sequence-specific DNA recognition subunit of LARC at beta-globin LCR PMID:16217013; VDRE-binding protein competing with VDR-RXR; overexpression causes VDR-normal HVDRR (dismech Vitamin_D-Dependent_Rickets_Type_2B) [PMID:12716975, PMID:17071612, PMID:21123297]. Added NEW GO:0000976 transcription cis-regulatory region binding (matches the dismech node, which marks it INCREASED).