Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Automatic assignment of GO terms using logical inference, based on on inter-ontology links
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
Subcellular localization of the autoimmune regulator protein. characterization of nuclear targeting and transcriptional activation domain.
The autoimmune regulator (AIRE) is a DNA-binding protein.
APECED-causing mutations in AIRE reveal the functional domains of the protein.
Two novel mutations of the AIRE protein affecting its homodimerization properties.
Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening.
The autoimmune regulator PHD finger binds to non-methylated histone H3K4 to activate gene expression.
Structure and site-specific recognition of histone H3 by the PHD finger of human autoimmune regulator.
Aire's partners in the molecular control of immunological tolerance.
DAXX is a new AIRE-interacting protein.
Dominant Mutations in the Autoimmune Regulator AIRE Are Associated with Common Organ-Specific Autoimmune Diseases.
A new mutation site in the AIRE gene causes autoimmune polyendocrine syndrome type 1.
Positional cloning of the APECED gene.
An autoimmune disease, APECED, caused by mutations in a novel gene featuring two PHD-type zinc-finger domains.
AIRE PN batch curation notes
AIRE manual deep research fallback
Proteostasis PN projected annotations report
Mechanism for controlled assembly of transcriptional condensates by Aire.
Aire deficient mice develop multiple features of APECED phenotype and show altered immune response.
Aire controls the differentiation program of thymic epithelial cells in the medulla for the establishment of self-tolerance.
Autoimmune regulator deficiency results in decreased expression of CCR4 and CCR7 ligands and in delayed migration of CD4+ thymocytes.
Extrathymic Aire-expressing cells are a distinct bone marrow-derived population that induce functional inactivation of CD4+ T cells.
Mapping DNA-binding domains of the autoimmune regulator protein.
Unmodified histone H3K4 and DNA-dependent protein kinase recruit autoimmune regulator to target genes.
AIRE relies on Z-DNA to flag gene targets for thymic T cell tolerization.
A Germinal Center Checkpoint of AIRE in B Cells Limits Antibody Diversification.
AIRE functions as an E3 ubiquitin ligase.
NMR structure of the first PHD finger of autoimmune regulator protein (AIRE1). Insights into autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) disease.
Subcellular expression of autoimmune regulator is organized in a spatiotemporal manner.