BNIP3 notes

Deep research was not run: falcon times out in this environment and perplexity-lite is not installed. These notes are based on the cached publications and the UniProt record.

Core biology

• An LC3-binding autophagy receptor for mitochondria and ER PMID:22505714
• The LIR is needed for mitophagy and ER-phagy but not for pro-death activity PMID:22505714
• Homodimerizes through its TM domain, which is required for autophagy PMID:22505714.
• With BNIP3L, required for hypoxia-induced autophagy PMID:19273585.
• Cell death is necrosis-like and goes through the PT pore PMID:10891486

Curation decisions

• Cell-death terms were kept as non-core.
• Positive regulation of mitochondrial fission (PMID:20436456) was marked as over-annotated, because the paper attributes fragmentation to inhibition of OPA1-mediated fusion.
• Two annotations were left UNDECIDED. Defence response to virus (PMID:9973195, a BNIP3alpha/BNIP3L paper, abstract only) shows only binding by viral anti-apoptotic proteins. For cellular response to mechanical stimulus (PMID:19593445, a BAD paper), BNIP3 is not mentioned in the cached text.
• GO:0061753 is labelled obsolete by GOA, and the IEA row was removed.
• All 84 protein binding rows were removed.