Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
UTX and JMJD3 are histone H3K27 demethylases involved in HOX gene regulation and development.
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First identification of jmjd-3.1 (F18E9.5) as C. elegans JMJD3 ortholog
"mutation of F18E9.5, a Caenorhabditis elegans JMJD3 orthologue"
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RNAi knockdown causes abnormal gonad development
"mutation of F18E9.5, a Caenorhabditis elegans JMJD3 orthologue, or inhibition of its expression, results in abnormal gonad development"
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Established H3K27 demethylase activity for JMJD3 family
"UTX and JMJD3 are histone H3K27 demethylases involved in HOX gene regulation and development"
Transdifferentiation. Sequential histone-modifying activities determine the robustness of transdifferentiation.
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Direct demonstration of H3K27me3/me2 demethylase activity
"a conserved H3K27me3/me2 demethylase, JMJD-3.1"
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Required for Y-to-PDA transdifferentiation
"JMJD-3.1, and the H3K4 methyltransferase Set1 complex cooperate to ensure invariant transdifferentiation (Td) of postmitotic Caenorhabditis elegans hindgut cells into motor neurons"
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Functions cell-autonomously with catalytic activity required
"robust conversion requires stepwise histone-modifying activities"
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Nuclear localization demonstrated
"functionally partitioned into discrete phases of Td through nuclear degradation of JMJD-3.1"
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Interacts with transcription factors including UNC-3
"phase-specific interactions with transcription factors that have conserved roles in cell plasticity and terminal fate selection"
The C. elegans H3K27 demethylase UTX-1 is essential for normal development, independent of its enzymatic activity.
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UTX-1 is dominant developmental H3K27 demethylase
"UTX-1 regulates global levels of H3K27me2/3 in C. elegans"
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JMJD-3.1 paralogs contribute to locus-specific H3K27 demethylation
"the loss of utx-1 leads to a more severe phenotype than the loss of jmjd-3.1, which only influences gonadal processes at high temperature and moderately reduces fertility"
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Triple jmjd-3.1/3.2/3.3 deletion increases global H3K27me3
"We generated mutant animals carrying mutations in all three JMJD3-like genes and, unexpectedly, we did not detect any additional phenotypes in the triple mutants"
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UTX-1 associates with SET-16/MLL-like complexes
"Biochemical analysis identified UTX-1 as a component of a complex that includes SET-16(MLL)"
Two Conserved Histone Demethylases Regulate Mitochondrial Stress-Induced Longevity.
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jmjd-3.1 necessary and sufficient for UPRmt activation
"Reduction of function of the demethylases potently suppresses longevity and UPR(mt) induction, while gain of function is sufficient to extend lifespan in a UPR(mt)-dependent manner"
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jmjd-3.1 is a positive regulator of lifespan
"We identify the conserved histone lysine demethylases jmjd-1.2/PHF8 and jmjd-3.1/JMJD3 as positive regulators of lifespan in response to mitochondrial dysfunction across species"
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Evolutionarily conserved role in longevity signaling
"These findings illustrate an evolutionary conserved epigenetic mechanism that determines the rate of aging downstream of mitochondrial perturbations"
Deep research report on jmjd-3.1