Gene Ontology annotation through association of InterPro records with GO terms

Annotation inferences using phylogenetic trees

Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt

Gene Ontology annotation based on curation of immunofluorescence data

Combined Automated Annotation using Multiple IEA Methods

Identification of KIAA1018/FAN1, a DNA repair nuclease recruited to DNA damage by monoubiquitinated FANCD2.

Deficiency of FANCD2-associated nuclease KIAA1018/FAN1 sensitizes cells to interstrand crosslinking agents.

A genetic screen identifies FAN1, a Fanconi anemia-associated nuclease necessary for DNA interstrand crosslink repair.

FAN1 acts with FANCI-FANCD2 to promote DNA interstrand cross-link repair.

Human KIAA1018/FAN1 localizes to stalled replication forks via its ubiquitin-binding domain.

FAN1 activity on asymmetric repair intermediates is mediated by an atypical monomeric virus-type replication-repair nuclease domain.

DNA repair. Mechanism of DNA interstrand cross-link processing by repair nuclease FAN1.

DNA nucleases bind monoubiquitinated ID2 complex

DNA nucleases unhook the interstrand crosslink (ICL)

Ubiquitinated Fancd2 recruits Fan1 to stalled replication forks to prevent genome instability.

FAN1 removes triplet repeat extrusions via a PCNA- and RFC-dependent mechanism.