Annotation inferences using phylogenetic trees

Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt

PMID:19946888

Defining the membrane proteome of NK cells.

PMID:22190034

Global landscape of HIV-human protein complexes.

PMID:28302725

Ankyrin repeat and zinc-finger domain-containing 1 mutations are associated with infantile-onset inflammatory bowel disease.

PMID:29632312

Vms1 and ANKZF1 peptidyl-tRNA hydrolases release nascent chains from stalled ribosomes.

PMID:30244831

Release of Ubiquitinated and Non-ubiquitinated Nascent Chains from Stalled Mammalian Ribosomal Complexes by ANKZF1 and Ptrh1.

PMID:31011209

Mechanism for recycling tRNAs on stalled ribosomes.

PMID:32075755

ELAC1 Repairs tRNAs Cleaved during Ribosome-Associated Quality Control.

PMID:21896481

The general definition of the p97/valosin-containing protein (VCP)-interacting motif (VIM) delineates a new family of p97 cofactors.

Defines the VCP-interacting motif (VIM, minimal consensus RX5AAX2R) and identifies ZNF744/ANKZF1 as a member of the VIM-containing p97/VCP cofactor family; the VIM is necessary and sufficient for binding the p97 N-terminal domain.

PMID:38412259

Ribosomal quality control factors inhibit repeat-associated non-AUG translation from GC-rich repeats.

Depletion of the RQC factors NEMF, LTN1 and ANKZF1 increases accumulation of repeat-associated non-AUG (RAN) translation products from G4C2 (C9ORF72) and CGG (FMR1) repeats, while their overexpression reduces RAN products in reporters and in C9ALS/FTD patient iPSC-derived neurons.

PMID:38388640

Stalled translation by mitochondrial stress upregulates a CNOT4-ZNF598 ribosomal quality control pathway important for tissue homeostasis.

Mitochondrial stress upregulates a CNOT4-ZNF598 ribosome-associated quality-control pathway whose downstream steps include ANKZF1-mediated release of stalled nascent chains, linking RQC to mitochondrial and tissue homeostasis.

PMID:37158785

Human ESC-derived vascular cells promote vascular regeneration in a HIF-1alpha dependent manner.

ANKZF1 is reported as a HIF-1alpha effector; transcriptional inactivation of ANKZF1 in human mesenchymal stem cells impairs pro-angiogenic processes under hypoxia.

PMID:31257922

High ANKZF1 expression is associated with poor overall survival and recurrence-free survival in colon cancer.

A TCGA bioinformatic analysis reports that high ANKZF1 expression is associated with poorer overall survival and recurrence-free survival in colon cancer; this is a correlative expression-outcome association.

Reactome:R-HSA-9948299

Ribosome-associated quality control

Reactome:R-HSA-9948427

ANKZF1 cleaves the peptidyl-tRNA in VCP hexamer:LTN1:NEMF:60S ribosome subunit:peptidyl-tRNA with K48polyUb-nascent peptide

file:human/ANKZF1/ANKZF1-uniprot.txt

UniProt record for human ANKZF1

file:human/ANKZF1/ANKZF1-notes.md

ANKZF1 curation notes

file:projects/PROTEOSTASIS/reports/pn_projection/pn_projected_gene_go_summary.tsv

Proteostasis Network projected GO summary

file:projects/PROTEOSTASIS/reports/pn_projection/pn_projected_candidate_additions.tsv

Proteostasis Network projected candidate additions

file:projects/PROTEOSTASIS/mappings/mitochondrial_proteostasis.yaml

Proteostasis Network mitochondrial proteostasis mappings

file:projects/PROTEOSTASIS/reports/pn_mapping_audit/current_mapping_scrutiny.tsv

Proteostasis Network mapping audit