Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Gene Ontology annotation based on curation of immunofluorescence data
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Automatic assignment of GO terms using logical inference, based on on inter-ontology links
Gene Ontology annotation of human sequence-specific DNA binding transcription factors (DbTFs) based on the TFClass database
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
Regulated nuclear-cytoplasmic localization of interferon regulatory factor 3, a subunit of double-stranded RNA-activated factor 1.
Analyses of virus-induced homomeric and heteromeric protein associations between IRF-3 and coactivator CBP/p300.
A small domain of CBP/p300 binds diverse proteins: solution structure and functional studies.
Involvement of TIRAP/MAL in signaling for the activation of interferon regulatory factor 3 by lipopolysaccharide.
Interaction between the HCV NS3 protein and the host TBK1 protein leads to inhibition of cellular antiviral responses.
Crystal structure of IRF-3 in complex with CBP.
Hepatitis C virus protease NS3/4A cleaves mitochondrial antiviral signaling protein off the mitochondria to evade innate immunity.
The GRIP1:IRF3 interaction as a target for glucocorticoid receptor-mediated immunosuppression.
Distinct functions of IRF-3 and IRF-7 in IFN-alpha gene regulation and control of anti-tumor activity in primary macrophages.
Type I interferon [corrected] gene induction by the interferon regulatory factor family of transcription factors.
Inhibition of retinoic acid-inducible gene I-mediated induction of beta interferon by the NS1 protein of influenza A virus.
Structure of IRF-3 bound to the PRDIII-I regulatory element of the human interferon-beta enhancer.
An atomic model of the interferon-beta enhanceosome.
Involvement of the ubiquitin-like domain of TBK1/IKK-i kinases in regulation of IFN-inducible genes.
Regulation of IRF-3-dependent innate immunity by the papain-like protease domain of the severe acute respiratory syndrome coronavirus.
S-glutathionylation of IRF3 regulates IRF3-CBP interaction and activation of the IFN beta pathway.
The DEAD-box helicase DDX3X is a critical component of the TANK-binding kinase 1-dependent innate immune response.
Viral targeting of DEAD box protein 3 reveals its role in TBK1/IKKepsilon-mediated IRF activation.
Negative feedback regulation of cellular antiviral signaling by RBCK1-mediated degradation of IRF3.
Structural basis for suppression of a host antiviral response by influenza A virus.
The adaptor protein MITA links virus-sensing receptors to IRF3 transcription factor activation.
Ebola virus protein VP35 impairs the function of interferon regulatory factor-activating kinases IKKepsilon and TBK-1.
ISG56 is a negative-feedback regulator of virus-triggered signaling and cellular antiviral response.
Influenza A virus NS1 targets the ubiquitin ligase TRIM25 to evade recognition by the host viral RNA sensor RIG-I.
Regulation of immunity and oncogenesis by the IRF transcription factor family.
Positive regulation of interferon regulatory factor 3 activation by Herc5 via ISG15 modification.
Reconstitution of the RIG-I pathway reveals a signaling role of unanchored polyubiquitin chains in innate immunity.
The transcription factor MafB antagonizes antiviral responses by blocking recruitment of coactivators to the transcription factor IRF3.
Tom70 mediates activation of interferon regulatory factor 3 on mitochondria.
ZAPS is a potent stimulator of signaling mediated by the RNA helicase RIG-I during antiviral responses.
MAVS forms functional prion-like aggregates to activate and propagate antiviral innate immune response.
Mapping a dynamic innate immunity protein interaction network regulating type I interferon production.
Toward an understanding of the protein interaction network of the human liver.
Activation of STAT6 by STING is critical for antiviral innate immunity.
STING specifies IRF3 phosphorylation by TBK1 in the cytosolic DNA signaling pathway.
Structure of STING bound to cyclic di-GMP reveals the mechanism of cyclic dinucleotide recognition by the immune system.
Tetraspanin 6 (TSPAN6) negatively regulates retinoic acid-inducible gene I-like receptor-mediated immune signaling in a ubiquitination-dependent manner.
DNA-binding specificities of human transcription factors.
Inducible interleukin 32 (IL-32) exerts extensive antiviral function via selective stimulation of interferon λ1 (IFN-λ1).
Structural insights into the functions of TBK1 in innate antimicrobial immunity.
SARS coronavirus papain-like protease inhibits the type I interferon signaling pathway through interaction with the STING-TRAF3-TBK1 complex.
RIOK3 is an adaptor protein required for IRF3-mediated antiviral type I interferon production.
Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.
Tom70 mediates Sendai virus-induced apoptosis on mitochondria.
Phosphorylation of innate immune adaptor proteins MAVS, STING, and TRIF induces IRF3 activation.
Haploinsufficiency of TBK1 causes familial ALS and fronto-temporal dementia.
TRIM-mediated precision autophagy targets cytoplasmic regulators of innate immunity.
DDX3 directly regulates TRAF3 ubiquitination and acts as a scaffold to co-ordinate assembly of signalling complexes downstream from MAVS.
Impact of cytosine methylation on DNA binding specificities of human transcription factors.
ZDHHC11 modulates innate immune response to DNA virus by mediating MITA-IRF3 association.
C6orf106 is a novel inhibitor of the interferon-regulatory factor 3-dependent innate antiviral response.
The EF-Hand Protein CALML6 Suppresses Antiviral Innate Immunity by Impairing IRF3 Dimerization.
DDX56 inhibits type I interferon by disrupting assembly of IRF3-IPO5 to inhibit IRF3 nucleus import.
TRAF3IP3 mediates the recruitment of TRAF3 to MAVS for antiviral innate immunity.
LYAR Suppresses Beta Interferon Induction by Targeting Phosphorylated Interferon Regulatory Factor 3.
Papain-like protease regulates SARS-CoV-2 viral spread and innate immunity.
IRF1 Promotes the Innate Immune Response to Viral Infection by Enhancing the Activation of IRF3.
SARS-CoV-2 Membrane Protein Inhibits Type I Interferon Production Through Ubiquitin-Mediated Degradation of TBK1.
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Membrane (M) and Spike (S) Proteins Antagonize Host Type I Interferon Response.
Coronaviruses exploit a host cysteine-aspartic protease for replication.
Metabolic enzyme UAP1 mediates IRF3 pyrophosphorylation to facilitate innate immune response.
MicroRNA-4691-3p inhibits the inflammatory response by targeting STING in human dental pulp cells: A laboratory investigation.
PBLD promotes IRF3 mediated the type I interferon (IFN-I) response and apoptosis to inhibit viral replication.
USP5 inhibits anti-RNA viral innate immunity by deconjugating K48-linked unanchored and K63-linked anchored ubiquitin on IRF3.
Identification of a member of the interferon regulatory factor family that binds to the interferon-stimulated response element and activates expression of interferon-induced genes.
Virus-dependent phosphorylation of the IRF-3 transcription factor regulates nuclear translocation, transactivation potential, and proteasome-mediated degradation.
Virus infection induces the assembly of coordinately activated transcription factors on the IFN-beta enhancer in vivo.
Expression of IFN-induced genes
p-T,4S-IRF3:p-T,4S-IRF3:CREBBP, EP300 binds promoters of Interferon-beta
Translocation of phosphorylated IRF3,IRF7 dimers into nucleus
CREBBP, EP300 binds p-T,4S-IRF3:p-T,4S-IRF3
VAF/pIRF7:CBP/p300 binds the promoters of type-I IFN genes
Formation of VAF (virus-activated factor) complex
Dimerization of Phospho IRF3 or phospho IRF7
Expression of IFNG-stimulated genes
Phosphorylation and release of IRF3
Phosphorylation of IRF-3/IRF7 and their release from the activated TLR complex
IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR4
Dimerization of phosphorylated IRF3/IRF7
Dimerized phospho-IRF3/IRF7 is transported to the nucleus
STING recruits TBK1 and IRF3
Dimerized phospho-IRF3 migrates to the nucleus
TBK1 is phosphorylated within STING:TBK1:IRF3 complex
IRF3 is phosphorylated by TBK1
Beta-catenin enhances association of IRF3 with CBP/p300
NLRP4 and DTX4 associate with p-S172-TBK1 within STING:TBK1:IRF3
DTX4 ubiquitinates p-S172-TBK1 within NLRP4:DTX4:STING:TBK1:IRF3
Phosphorylation of IRF-3/IRF7 and their release from the activated TLR3 complex
IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR3
Phosphorylation and release of IRF3/IRF7
Interaction of PIN1 with p-IRF3
PIN1 mediated IRF3 degradation
HSP90 binds TBK1 and IRF3
MAVS:TOMM70 recruits HSP90:TBK1:IRF3
SARS-CoV-2 nsp3 deISGylates ISGylated IRF3
SARS-CoV-2 nsp3 cleaves IRF3
SARS-CoV-1 nsp3 binds to IRF3
SARS-CoV-1 8b binds to IRF3
Dimerized phospho-IRF3, IRF7 is transported to the nucleus
Characterization of a novel isoform of murine interferon regulatory factor 3.