Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
TreeGrafter-generated GO annotations
Combined Automated Annotation using Multiple IEA Methods
UniProt Swiss-Prot record for human NDEL1 (Q9GZM8)
NDEL1: donkey-human sequence comparison
PTHR10921 NudE family review
UniProt record for donkey NDEL1 (A0A9L0IJ72)
A LIS1/NUDEL/cytoplasmic dynein heavy chain complex in the developing and adult nervous system.
Nudel functions in membrane traffic mainly through association with Lis1 and cytoplasmic dynein.
Ndel1 operates in a common pathway with LIS1 and cytoplasmic dynein to regulate cortical neuronal positioning.
Nudel contributes to microtubule anchoring at the mother centriole and is involved in both dynein-dependent and -independent centrosomal protein assembly.
DISC1-NDEL1/NUDEL protein interaction, an essential component for neurite outgrowth, is modulated by genetic variations of DISC1.
Cenp-F links kinetochores to Ndel1/Nde1/Lis1/dynein microtubule motor complexes.
The structure of the coiled-coil domain of Ndel1 and the basis of its interaction with Lis1, the causal protein of Miller-Dieker lissencephaly.
Nudel and FAK as antagonizing strength modulators of nascent adhesions through paxillin.
Distinct dose-dependent cortical neuronal migration and neurite extension defects in Lis1 and Ndel1 mutant mice.
LIS1 and NudE induce a persistent dynein force-producing state.
The cytoskeletal protein Ndel1 regulates dynamin 2 GTPase activity.
A Cdk5-dependent switch regulates Lis1/Ndel1/dynein-driven organelle transport in adult axons.
Ndel1 disfavors dynein-dynactin-adaptor complex formation in two distinct ways.
Conserved roles for the dynein intermediate chain and Ndel1 in assembly and activation of dynein.
Novel lissencephaly-associated NDEL1 variant reveals distinct roles of NDE1 and NDEL1 in nucleokinesis and human cortical malformations.
NDEL1 (donkey): comparison of all UniProt gene models with human NDEL1
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The benchmark model A0A9L0IJ72 is collinear with human NDEL1 isoform 1 through residue 338 and replaces the last seven human residues with a 143-residue tail found in no human isoform.
"It is collinear with human isoform 1 through
residue 338"